Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
EJ Sun, M Wankell, P Palamuthusingam, C McFarlane… - Biomedicines, 2021 - mdpi.com
Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …
Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
Q Zhou, VWY Lui, W Yeo - Future oncology, 2011 - Taylor & Francis
Despite recent advances in the understanding of the biologic basis of hepatocellular
carcinoma (HCC) development, the clinical management of the disease remains a major …
carcinoma (HCC) development, the clinical management of the disease remains a major …
The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …
[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
Targeting EGFR/PI3K/AKT/mTOR signaling in hepatocellular carcinoma
J Bang, M Jun, S Lee, H Moon, SW Ro - Pharmaceutics, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) poses a significant global health concern, with its
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …
incidence steadily increasing. The development of HCC is a multifaceted, multi-step process …
[HTML][HTML] Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing
F Janku, AO Kaseb, AM Tsimberidou, RA Wolff… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Understanding genetic aberrations in cancer leads to discovery of new targets for cancer
therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully …
therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully …
PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?
Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
Therapeutic potential of targeting PI3K/AKT pathway in treatment of colorectal cancer: rational and progress
A Bahrami, M Khazaei, M Hasanzadeh… - Journal of cellular …, 2018 - Wiley Online Library
ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
PI3K/Akt/mTOR signaling pathway: role in esophageal squamous cell carcinoma, regulatory mechanisms and opportunities for targeted therapy
Q Luo, R Du, W Liu, G Huang, Z Dong, X Li - Frontiers in oncology, 2022 - frontiersin.org
Esophageal squamous cell carcinoma (ESCC), is the most common type of esophageal
cancer worldwide, mainly occurring in the Asian esophageal cancer belt, including northern …
cancer worldwide, mainly occurring in the Asian esophageal cancer belt, including northern …