Until recently, research on (S)-(-)-nicotine (1, hereafter simply nicotine) and nicotinic
acetylcholine receptors (nAChRs) emphasized two principal aspects. The first was the …

Neuronal nicotinic acetylcholine receptors (nAChRs) have been a target for drug discovery
efforts, primarily for CNS indications, for the past two decades. While nicotine and related …

Although the molecular biology of neuronal nicotinic acetylcholine receptors (nAChRs)
provides evidence for multiple receptor subtypes, few selective pharmacological tools exist …

Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-
gated cation channels with diverse structures and properties. In contrast to the muscular …

The plant alkaloid, nicotine (Fig. 1), is a commonly used psychoactive drug that is orally self-
administered via the chewing or combustion of tobacco products, the latter typically via …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels
differently expressed in the nervous system where, by responding to the endogenous …