Inflammation resolution and the induction of granulocyte apoptosis by cyclin-dependent kinase inhibitor drugs
Inflammation is a necessary dynamic tissue response to injury or infection and it's resolution
is essential to return tissue homeostasis and function. Defective or dysregulated …
is essential to return tissue homeostasis and function. Defective or dysregulated …
Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation
JM Hallett, AE Leitch, NA Riley, R Duffin… - Trends in …, 2008 - cell.com
Resolution of inflammation requires the effective downregulation of key inflammatory cells
such as neutrophils and eosinophils, which normally undergo programmed cell death …
such as neutrophils and eosinophils, which normally undergo programmed cell death …
Modulation of granulocyte apoptosis can influence the resolution of inflammation
Apoptosis of granulocytes and the subsequent clearance of apoptotic cells are important
processes for the successful resolution of inflammation. Signalling pathways, including …
processes for the successful resolution of inflammation. Signalling pathways, including …
Switching off key signaling survival molecules to switch on the resolution of inflammation
DA Perez, JP Vago, RM Athayde… - Mediators of …, 2014 - Wiley Online Library
Inflammation is a physiological response of the immune system to injury or infection but may
become chronic. In general, inflammation is self‐limiting and resolves by activating a …
become chronic. In general, inflammation is self‐limiting and resolves by activating a …
Targeting granulocyte apoptosis: mechanisms, models, and therapies
The inflammatory process is a complex series of tightly controlled cellular and biochemical
events initiated by the immune system, which has evolved to eliminate or contain infectious …
events initiated by the immune system, which has evolved to eliminate or contain infectious …
Role of neutrophil apoptosis in the resolution of inflammation
D El Kebir, JG Filep - The Scientific World Journal, 2010 - Wiley Online Library
Neutrophil granulocytes play a central role in host defense to infection and tissue injury.
Their timely removal is essential for resolution of inflammation. Increasing evidence …
Their timely removal is essential for resolution of inflammation. Increasing evidence …
Resolution of inflammation: mechanisms and opportunity for drug development
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets
C Ward, I Dransfield, ER Chilvers, C Haslett… - Trends in …, 1999 - cell.com
Resolution of inflammation involves the clearance of excess or effete inflammatory cells by a
process of physiological programmed cell death (apoptosis) and the subsequent recognition …
process of physiological programmed cell death (apoptosis) and the subsequent recognition …
Regulation of apoptotic cell clearance during resolution of inflammation
Programmed cell death (apoptosis) has an important role in the maintenance of tissue
homeostasis as well as the progression and ultimate resolution of inflammation. During …
homeostasis as well as the progression and ultimate resolution of inflammation. During …
Programmed cell death and its role in inflammation
Y Yang, G Jiang, P Zhang, J Fan - Military Medical Research, 2015 - Springer
Cell death plays an important role in the regulation of inflammation and may be the result of
inflammation. The maintenance of tissue homeostasis necessitates both the recognition and …
inflammation. The maintenance of tissue homeostasis necessitates both the recognition and …