Inflammation resolution and the induction of granulocyte apoptosis by cyclin-dependent kinase inhibitor drugs

JA Cartwright, CD Lucas, AG Rossi - Frontiers in pharmacology, 2019 - frontiersin.org
Inflammation is a necessary dynamic tissue response to injury or infection and it's resolution
is essential to return tissue homeostasis and function. Defective or dysregulated …

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

JM Hallett, AE Leitch, NA Riley, R Duffin… - Trends in …, 2008 - cell.com
Resolution of inflammation requires the effective downregulation of key inflammatory cells
such as neutrophils and eosinophils, which normally undergo programmed cell death …

Modulation of granulocyte apoptosis can influence the resolution of inflammation

AG Rossi, JM Hallett, DA Sawatzky, MM Teixeira… - 2007 - portlandpress.com
Apoptosis of granulocytes and the subsequent clearance of apoptotic cells are important
processes for the successful resolution of inflammation. Signalling pathways, including …

Switching off key signaling survival molecules to switch on the resolution of inflammation

DA Perez, JP Vago, RM Athayde… - Mediators of …, 2014 - Wiley Online Library
Inflammation is a physiological response of the immune system to injury or infection but may
become chronic. In general, inflammation is self‐limiting and resolves by activating a …

Targeting granulocyte apoptosis: mechanisms, models, and therapies

R Duffin, AE Leitch, S Fox, C Haslett… - Immunological …, 2010 - Wiley Online Library
The inflammatory process is a complex series of tightly controlled cellular and biochemical
events initiated by the immune system, which has evolved to eliminate or contain infectious …

Role of neutrophil apoptosis in the resolution of inflammation

D El Kebir, JG Filep - The Scientific World Journal, 2010 - Wiley Online Library
Neutrophil granulocytes play a central role in host defense to infection and tissue injury.
Their timely removal is essential for resolution of inflammation. Increasing evidence …

Resolution of inflammation: mechanisms and opportunity for drug development

AL Alessandri, LP Sousa, CD Lucas, AG Rossi… - Pharmacology & …, 2013 - Elsevier
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets

C Ward, I Dransfield, ER Chilvers, C Haslett… - Trends in …, 1999 - cell.com
Resolution of inflammation involves the clearance of excess or effete inflammatory cells by a
process of physiological programmed cell death (apoptosis) and the subsequent recognition …

Regulation of apoptotic cell clearance during resolution of inflammation

S Arienti, ND Barth, DA Dorward, AG Rossi… - Frontiers in …, 2019 - frontiersin.org
Programmed cell death (apoptosis) has an important role in the maintenance of tissue
homeostasis as well as the progression and ultimate resolution of inflammation. During …

Programmed cell death and its role in inflammation

Y Yang, G Jiang, P Zhang, J Fan - Military Medical Research, 2015 - Springer
Cell death plays an important role in the regulation of inflammation and may be the result of
inflammation. The maintenance of tissue homeostasis necessitates both the recognition and …