The regrowth capacity of damaged neurons governs neuroregeneration and functional
recovery after nervous system trauma. Over the past few decades, various intrinsic and …

An experimental method has been developed to investigate the cellular responses to central
nervous system (CNS) injury using the fruit-fly Drosophila. Understanding repair and …

Highlights•Powerful genetics, a simplified nervous system, and amenability to live imaging
make Drosophila an ideal model system to study mechanisms of axon and dendrite …

Despite important progress made in understanding the mechanisms of axon regeneration,
how a neuron responds to an injury and makes a regenerative decision remains unclear. In …

Drosophila melanogaster is a leading genetic model system in nervous system development
and disease research. Using the power of fly genetics in traumatic axonal injury research …

Live-imaging technology has markedly advanced in the field of neural injury and axon
degeneration; however, studies are still predominantly performed in in vitro settings such as …

Maintaining neuronal connectivity in the face of injury and disease is a major challenge for
the nervous system. The great length of axons makes them particularly vulnerable to insult …

Axon degeneration is the pivotal pathological event of acute traumatic neural injury as well
as many chronic neurodegenerative diseases. It is an active cellular program and yet …

The mammalian central nervous system (CNS) exhibits limited regenerative capacity and
the mechanisms that mediate its regeneration are not fully understood. Here, we present a …

Both cell-intrinsic and extrinsic pathways govern axon regeneration, but only a limited
number of factors have been identified and it is not clear to what extent axon regeneration is …