Randomized clinical trials have become the accepted scientific standard for evaluating
therapeutic efficacy. Contradictory results from multiple randomized clinical trials on the …

The randomized clinical trial is the preferred research design for evaluating competing
diagnostic and therapeutic alternatives, but confidence in the conclusions from a …

Randomized controlled trials remain the gold standard study design and yield the highest
level of scientific credence. However, recognition of the limitations of the randomized …

Evidence from randomized controlled clinical trials is widely accepted as the only sound
basis for assessing the efficacy of new medical treatments. Statistical methods play a key …

Controlled clinical trials constitute the ideal scientific approach for obtainн ing information on
clinical treatments. Properly designed, conducted, anaн lyzed, and reported, they provide a …

OBJECTIVE: To investigate whether a single trial can provide sufficiently robust evidence to
warrant clinical implementation of its results. Trial-specific factors, such as subject selection …

Unlike other discussants in this symposium who were asked to review the manuscript of one
of the speakers, I was provided with a different charge. I was given the opportunity to discuss …

This is a comment on" A comparison of observational studies and randomized, controlled
trials." N Engl J Med. 2000 Jun 22; 342 (25): 1878-86. This is a comment on" Randomized …

To achieve the goal of validity, the randomized clinical trial has emerged as the scientific"
gold standard" for evaluating therapies in clinical medicine. Regardless of how well …

Context.—The extent of concordance between meta-analyses and large trials on the same
topic has been investigated with different protocols. Inconsistent conclusions created …