DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridin-2-ones

L Wang, G Zhu, W Tang, T Lu, D Du - Tetrahedron, 2016 - Elsevier
A general and simple synthesis of 2, 4, 6-trisubstituted pyridines and fused pyridine-2-ones
from bromoacetic acid is developed via a DMAP-promoted in situ activation strategy. In this …

Divergent synthesis of highly substituted pyridines and benzenes from dienals, alkynes, and sulfonyl azides

H Luo, Y Li, L Du, X Xin, T Wang, J Han, Y Tian… - Organic …, 2021 - ACS Publications
Divergent synthesis is extremely important for the highly efficient preparation of structurally
diverse target molecules. Herein, we describe a multicomponent cascade reaction, which …

One-pot reactions for modular synthesis of polysubstituted and fused pyridines

Z Song, X Huang, W Yi, W Zhang - Organic letters, 2016 - ACS Publications
A 2-fluoro-1, 3-dicarbonyl-initiated one-pot Michael addition/[5+ 1] annulation/
dehydrofluorinative aromatization reaction sequence is introduced for regioselective …

Efficient synthesis of highly substituted pyrroles through a Pd (OCOCF 3) 2-catalyzed cascade reaction of 2-alkenal-1, 3-dicarbonyl compounds with primary amines

W Yang, L Huang, H Liu, W Wang, H Li - Chemical communications, 2013 - pubs.rsc.org
We describe an unprecedented Pd (OCOCF3) 2-catalyzed cascade process for the
synthesis of highly functionalized 1, 2, 3, 5-tetrasubstituted pyrroles with high efficiency …

Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH4I-Promoted Three-Component Tandem Reaction

F Fang, J Xia, S Quan, S Chen… - The Journal of Organic …, 2023 - ACS Publications
A facile and practical approach for the preparation of substituted pyrimidines from ketones,
NH4OAc, and N, N-dimethylformamide dimethyl acetal has been described. This NH4I …

DABCO-promoted three-component reaction between amines, dialkyl acetylenedicarboxylates, and glyoxal

K Ramesh, SN Murthy, K Karnakar, YVD Nageswar - Tetrahedron letters, 2011 - Elsevier
DABCO-promoted three-component reaction between amines, dialkyl
acetylenedicarboxylates, and glyoxal - ScienceDirect Skip to main contentSkip to article …

Synthesis of Poly‐Substituted Pyridines via Noble‐Metal‐Free Cycloaddition of Ketones and Imines

Y Mao, H Mao, J Xu, T Liu, B Liu, Q Tan… - Chemistry–An Asian …, 2021 - Wiley Online Library
An eco‐friendly and noble‐metal‐free formal [4+ 2] cycloaddition reaction was developed for
the efficient synthesis of biologically interesting poly‐substituted pyridines from easily …

Flexible Construction Approach to the Synthesis of 1, 5-Substituted Pyrrole-3-carbaldehydes from 5-Bromo-1, 2, 3-triazine

CC Wu, R Ambre, MH Lee, JJ Shie - Organic Letters, 2022 - ACS Publications
We report an efficient and mild tandem catalytic process for the synthesis of functionalized
pyrrole-3-carbaldehydes. These compounds were obtained by a one-pot three-component …

A regioselective approach to trisubstituted 2 (or 6)-arylaminopyrimidine-5-carbaldehydes and their application in the synthesis of structurally and electronically unique …

RL Beingessner, BL Deng, PE Fanwick… - The Journal of Organic …, 2008 - ACS Publications
An efficient regioselective synthesis of trisubstituted 2 (or 6)-arylaminopyrimidine-5-
carbaldehydes has been developed via an SNAr reaction of 2, 4, 6-trichloropyrimidine-5 …

Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3, 4-diarylated pyridines

SK Guchhait, N Hura, K Sinha, D Panda - RSC advances, 2017 - pubs.rsc.org
An efficient route for the synthesis of penta-substituted/functionalized-3, 4-diarylated
pyridines, biologically important templates, via pyridine C3-arylation of nicotinic acids has …