Myostatin is a transforming growth factor-β family member that acts as a negative regulator
of skeletal muscle mass. To identify possible myostatin inhibitors that may have applications …

Myostatin is a transforming growth factor-ß family member that normally acts to limit skeletal
muscle growth. Mice genetically engineered to lack myostatin activity have about twice the …

Myostatin is a member of the TGF-β superfamily that is essential for proper regulation of
skeletal muscle growth. As do other TGF-β superfamily members, myostatin signals into the …

Myostatin, also known as growth and differentiation factor 8, is a member of the transforming
growth factor β superfamily that negatively regulates skeletal muscle mass (1). Recent …

Deletion or inhibition of myostatin in mammals has been demonstrated to markedly increase
muscle mass by hyperplasia, hypertrophy, or a combination of both. Despite a remarkably …

Follistatin is known to antagonise the function of several members of the TGF-β family of
secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth …

Myostatin, a transforming growth factor-β superfamily ligand, negatively regulates skeletal
muscle growth. Generation of the mature signaling peptide requires cleavage of pro …

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β
family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by …

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, has been
shown to be a negative regulator of myogenesis. Here we show that myostatin functions by …

Myostatin, a member of the TGFβ superfamily, is a potent and specific negative regulator of
skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing …