There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

Two dog adenosine receptors have been recently cloned. They were pharmacologically
characterized as an A1 and the A2a receptor, respectively. The adenosine A2a receptor is …

Adenosine A 2A receptor antagonism is a new therapeutic strategy in the symptomatic
treatment of Parkinson's disease (PD). This review addresses how adenosine A 2A …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

The drug treatment of Parkinson's disease (PD) is accompanied by a loss of drug efficacy,
the onset of motor complications, lack of effect on non-motor symptoms, and a failure to …

Adenosine is an endogenous purine nucleoside that regulates several physiological
functions, at the central and peripheral levels. Besides, adenosine has emerged as a major …

Adenosine A2A receptors are abundant in the caudate‐putamen and involved in the motor
control in several species. In MPTP‐treated monkeys, A2A receptor‐blockade with an …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

This book is the first definitive overview on adenosine receptor antagonists and their
application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine …