In higher eukaryotic cells, chromosomes are folded inside the nucleus. Recent advances in
whole-genome mapping technologies have revealed the multiscale features of 3D genome …

Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

The structural organization of the genome plays an important role in multiple aspects of
genome function. Understanding how genomic sequence influences 3D organization can …

The advent of high-resolution chromosome conformation capture assays (such as 5C, Hi-C
and Pore-C) has allowed for unprecedented sequence-level investigations into the structure …

Abstract Motivation Three-dimensional (3D) genome organization plays important functional
roles in cells. User-friendly tools for reconstructing 3D genome models from chromosomal …

A multitude of sequencing-based and microscopy technologies provide the means to
unravel the relationship between the three-dimensional organization of genomes and key …

To learn how genomic sequence influences multiscale three-dimensional (3D) genome
architecture, this manuscript presents a sequence-based deep-learning approach, Orca, that …

The structural organization of the genome is emerging as a crucial regulator of the cell state,
affecting gene transcription, DNA replication, and repair. Over the last twenty years …

Topologically associating domains (TADs) have emerged as basic structural and functional
units of genome organization and have been determined by many computational methods …

Abstract The three-dimensional (3D) architecture of a genome is non-random and known to
facilitate the spatial colocalization of regulatory elements with the genes they regulate …