[HTML][HTML] The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression

Y Fang, H Guo, Q Wang, C Liu, S Ge… - Frontiers in …, 2022 - frontiersin.org
Background: Depression is a common and potentially life-threatening mental illness, and
currently, there is a lack of effective treatment. It has been reported that dehydrocorydaline …

[HTML][HTML] 4-Methylesculetin ameliorates LPS-induced depression-like behavior through the inhibition of NLRP3 inflammasome

K Choudhary, SR Prasad, KB Lokhande… - Frontiers in …, 2023 - frontiersin.org
The pathophysiology of depression is heavily dependent on inflammation. Evidence
suggests that the etiology of depression is linked with NLRP3 inflammasome-induced …

[HTML][HTML] Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity …

Z Qin, DD Shi, W Li, D Cheng, YD Zhang… - Journal of …, 2023 - Springer
Objectives Neuroinflammation has been suggested that affects the processing of
depression. There is renewed interest in berberine owing to its anti-inflammatory effects …

[HTML][HTML] Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis

Y Zhou, Y Huang, W Ye, Z Chen, Z Yuan - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Depression is a common mental health disorder, and in recent years, the incidence of
various forms of depression has been on the rise. Most medications for depression are …

[HTML][HTML] The anti-depressive effects of hesperidin and the relative mechanisms based on the NLRP3 inflammatory signaling pathway

L Xie, Z Gu, H Liu, B Jia, Y Wang, M Cao… - Frontiers in …, 2020 - frontiersin.org
There is increasing evidence showing that inflammation is associated with depression in
humans. Hesperidin, a natural bioflavonoid, has performed excellent effects on depression …

[HTML][HTML] Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

R Dang, M Wang, X Li, H Wang, L Liu, Q Wu… - Journal of …, 2022 - Springer
Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Astragalin exerted antidepressant-like action through SIRT1 signaling modulated NLRP3 inflammasome deactivation

Y Tong, H Fu, C Xia, W Song, Y Li, J Zhao… - ACS chemical …, 2020 - ACS Publications
Inflammation plays a key role in the pathogenesis of depression and antidepressant
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …

[HTML][HTML] Salidroside improves chronic stress induced depressive symptoms through microglial activation suppression

Y Fan, Y Bi, H Chen - Frontiers in Pharmacology, 2021 - frontiersin.org
Depression is a severe neurological disorder highly associated with chronic mental stress
stimulation, which involves chronic inflammation and microglial activation in the central …

[HTML][HTML] α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

B Xia, Y Tong, C Xia, C Chen, X Shan - Frontiers in Pharmacology, 2020 - frontiersin.org
α-Cyperone (Cy) is a major active compound of Cyperus rotundus that has various
pharmacological activities. But whether Cy possesses antidepressant effect is unknown. In …

CY-09 alleviates the depression-like behaviors via inhibiting NLRP3 inflammasome-mediated neuroinflammation in lipopolysaccharide-induced mice

Y Wang, YJ Liu, MM Zhang, H Zhou… - ACS Chemical …, 2022 - ACS Publications
Depression is a serious mental illness, mainly characterized as large mood swings and
sleep, diet, and cognitive function disorders. NLPR3, one of the inflammasomes that can be …