Circulating ACE2-expressing exosomes block SARS-CoV-2 infection as an innate antiviral mechanism
L El-Shennawy, AD Hoffmann, NK Dashzeveg, PJ Mehl… - BioRxiv, 2020 - biorxiv.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
coronavirus disease 2019 (COVID-19) with innate and adaptive immune response triggered …
coronavirus disease 2019 (COVID-19) with innate and adaptive immune response triggered …
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
L El-Shennawy, AD Hoffmann, NK Dashzeveg… - Nature …, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the
pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of …
pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of …
[HTML][HTML] ACE2‐enriched extracellular vesicles enhance infectivity of live SARS‐CoV‐2 virus
Extracellular vesicles (EVs) are nanoscale vesicles naturally released from cells that are
delimited by a lipid bilayer and cannot replicate (Van Niel et al., 2018). Growing evidence …
delimited by a lipid bilayer and cannot replicate (Van Niel et al., 2018). Growing evidence …
ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection
KL Ching, M de Vries, J Gago, K Dancel-Manning… - PLoS …, 2022 - journals.plos.org
Extracellular vesicles of endosomal origin, exosomes, mediate intercellular communication
by transporting substrates with a variety of functions related to tissue homeostasis and …
by transporting substrates with a variety of functions related to tissue homeostasis and …
NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity
X Lv, R Chen, T Liang, H Peng, Q Fang, S Xiao, S Liu… - Mbio, 2024 - Am Soc Microbiol
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
triggered a global pandemic, which severely endangers public health. Our and others' works …
triggered a global pandemic, which severely endangers public health. Our and others' works …
Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2
Continued emergence of SARS-CoV-2 variants of concern that are capable of escaping
vaccine-induced immunity highlights the urgency of developing new COVID-19 therapeutics …
vaccine-induced immunity highlights the urgency of developing new COVID-19 therapeutics …
SARS-CoV-2 takes the bait: Exosomes as endogenous decoys
S Fernbach, BG Hale - PLoS Biology, 2022 - journals.plos.org
Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are
deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with …
deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with …
Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy
JM Inal - Clinical Science, 2020 - portlandpress.com
The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent
of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that …
of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that …
[HTML][HTML] Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles
C Wu, Q Xu, H Wang, B Tu, J Zeng, P Zhao… - … Pharmaceutica Sinica B, 2022 - Elsevier
The spread of coronavirus disease 2019 (COVID-19) throughout the world has resulted in
stressful healthcare burdens and global health crises. Developing an effective measure to …
stressful healthcare burdens and global health crises. Developing an effective measure to …
[HTML][HTML] An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages
Rationale: Macrophages are the frontline immune cells in response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Angiotensin-converting …