Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver cirrhosis and
hepatocellular carcinoma. NAFLD is associated with metabolic disorders such as obesity …

The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated
transcription factor. While initially identified as an environmental sensor, this receptor has …

Liver cirrhosis is an increasing health burden and public health concern. Regardless of
etiology, patients with cirrhosis are at risk of a range of life-threatening complications …

The intestinal epithelial lining, together with factors secreted from it, forms a barrier that
separates the host from the environment. In pathologic conditions, the permeability of the …

Dysbiosis observed in autoimmune diseases is associated with decreased bacteria function
and diversity, impaired epithelial barrier, bacterial translocation, inflammation, and …

Commensal gut microbiota protects the immune defense of extra-intestinal organs. Gut
microbiota depletion by antibiotics can impair host antiviral immune responses and alter …

Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed
male and female individuals worldwide. Diagnosis of AIH is made clinically applying …

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
common liver disease worldwide in recent years. MASLD commonly presents as simple …

Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Many types of innate (natural killer cells, natural killer T cells, and Kupffer
cells/macrophages) and adaptive (T cells and B cells) immune cells are enriched within the …