Regio-controlled synthesis of unsymmetrical pyrazine-fused sinomenine derivatives and discriminate substitution effects on TNF-α inhibitory activity

T Zhou, J Hou, M Wang, L Ma, L Wu, S Wang, B Sun… - Tetrahedron, 2014 - Elsevier
A unified regio-controlled synthetic protocol combined with the use of Suzuki couplings, in a
diverse fashion, has been developed and successfully applied to the synthesis of various …

The pharmacokinetics, bioavailability and excretion of columbianetin acetate and its metabolite columbianetin were analysed in rat plasma by LC-MS/MS after …

X Jiao, J Li, X Yu, W Liu, J Tian, J He, H Jin, X Gao… - RSC …, 2015 - pubs.rsc.org
Angelicae pubescentis radix (APR) has been widely used in the clinic for the treatment of
rheumatoid arthritis. Columbianetin acetate and its metabolite columbianetin have various …

Toxicological evaluation of Antrodia cinnamomea in BALB/c mice

JB Chang, MF Wu, HF Lu, J Chou, MK Au, NC Liao… - in vivo, 2013 - iv.iiarjournals.org
Antrodia cinnamomea is a natural component of some herbal medicines used for treatment
of abdominal pain, hypertension and hepatocellular carcinoma in Taiwan and other …

Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS

C Li, C Yang, X Peng, Z Xiong… - Journal of chromatographic …, 2010 - academic.oup.com
A sensitive, specific method has been developed for simultaneous determination of
neoeriocitrin and naringin in rat plasma using liquid chromatography-tandem mass …

Anti-nociceptive and anti-inflammatory activities of visnagin in different nociceptive and inflammatory mice models

X Qi, K Aiyasamy, SK Alenezi, IM Alanazi… - Applied Biochemistry …, 2024 - Springer
Pain management has been a severe public health issue throughout the world. Acute pain if
not treated at the appropriate time can lead to chronic pain that can cause psychological and …

[HTML][HTML] Metabolic profile of danshen in rats by HPLC-LTQ-Orbitrap mass spectrometry

H Pang, M Jiang, Q Wang, X Wang, W Gao… - Journal of Zhejiang …, 2018 - ncbi.nlm.nih.gov
Danshen, the dried root of Salvia miltiorrhiza Bunge (Lamiaceae), is one of the traditional
Chinese medicines (TCMs) most commonly used for the treatment of cardiovascular and …

Comparative pharmacokinetics of naringin in rat after oral administration of chaihu-shu-gan-san aqueous extract and naringin alone

SQ Li, S Dong, ZH Su, HW Zhang, JB Peng, CY Yu… - Metabolites, 2013 - mdpi.com
Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing
seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer …

Pharmacokinetics and brain distribution differences of baicalin in rat underlying the effect of Panax notoginsenosides after intravenous administration

Y Yan-Fang, LI Zhi, XIN Wen-Feng, W Yong-Yan… - Chinese journal of …, 2014 - Elsevier
Baicalin (BA) is the most well-known flavonoid present in Radix Scutellariae. The aim of this
study was to explore whether the pharmacokinetic behavior of BA in rat brain can be …

Brain distribution pharmacokinetics and integrated pharmacokinetics of Panax Notoginsenoside R1, Ginsenosides Rg1, Rb1, Re and Rd in rats after intranasal …

Q Guo, P Li, Z Wang, Y Cheng, H Wu, B Yang… - … of Chromatography B, 2014 - Elsevier
Panax notoginseng saponins (PNS) constitute the main active components of a traditional
Chinese medicine, Panax notoginseng (Burk.) FH Chen (Sanqi). To investigate brain …

Development and validation of liquid chromatography–tandem mass spectrometry method for quantification of a potential anticancer triterpene saponin from seeds of …

X Hu, X Liu, M Gong, M Luan, Y Zheng, G Wu… - … of Chromatography B, 2014 - Elsevier
Abstract Nigella glandulifera Freyn et Sit is a folk medicinal plant, whose seeds show
significant anticancer activities attributed to triterpene saponins and volatile oil. In this study …