Certain class II MHC-peptide complexes are resistant to SDS-induced dissociation. This
property, which has been used as an in vivo as well as an in vitro peptide binding assay, is …

Abstract HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing
the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved …

Exogenous antigens are internalized by antigen-processing cells and processed within
vesicular compartments to produce antigenic peptides that bind to newly synthetized MHC II …

HLA-DM serves a critical function in the loading and editing of peptides on MHC class II
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …

HLA-DM catalyzes the release of invariant chain fragments from newly synthesized major
histocompatibility complex (MHC) class II molecules, stabilizes empty class II molecules, and …

Human histocompatibility leukocyte antigen (HLA)-DM is a major histocompatibility complex
(MHC)-like protein that catalyzes exchange of antigenic peptides from MHC class II …

The MHC is central to the adaptive immune response. The human MHC class II is encoded
by three different isotypes, HLA-DR,-DQ, and-DP, each being highly polymorphic. In contrast …

The invariant chain (Ii) prevents binding of ligands to major histocompatibility complex
(MHC) class II molecules in the endoplasmic reticulum and during intracellular transport …

The mechanism by which the peptide exchange factor HLA-DM catalyzes peptide loading
onto structurally homologous class II MHC proteins is an outstanding problem in antigen …

The major histocompatibility complex (MHC) class II molecules are highly polymorphic
membrane glycoproteins that bind peptide fragments of proteins and display them for …