Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that
catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from …

Normal immune surveillance depends on the ability of MHC class II molecules to bind
peptide antigens and carry them to the cell surface for display to T cells. To do this efficiently …

Class II major histocompatibility complex (MHC) proteins bind peptides and present them at
the cell surface for interaction with CD4+ T cells as part of the system by which the immune …

We have compared the intracellular transport and subcellular distribution of MHC class II-
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …

The MHC class II-like molecule HLA-DM (DM)(H-2M in mice) catalyzes the exchange of
CLIP for antigenic peptides in the endosomes of APCs. HLA-DO (DO)(H-2O in mice) is …

FRG Received April 12, 1991; Revised Manuscript Received June 18, 1991 abstract: The
acid release of endogenous peptides from immunoaffinity-pure human major histocom …

In class II major histocompatibility complex (MHC) proteins, residue β57 is usually aspartic
acid. Alleles carrying serine, valine, or alanine at this position are strongly correlated with …

Class II presentation mutants have mutations in the HLA-DMA or B genes and are defective
in the presentation of whole exogenous Ags restricted by HLA-DR,-DQ, and-DP. The …

Major histocompatibllity complex (MHC) class II molecules bind antigenic peptides rapidly
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …

Major histocompatibility complex (MHC) glycoproteins play an important role in the
development of an effective immune response. An important MHC function is the ability to …