Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
DA Weber, BD Evavold, PE Jensen - Science, 1996 - science.org
Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that
catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from …
catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from …
Structural principles of MHC class II antigen presentation.
CA Nelson, DH Fremont - Reviews in immunogenetics, 1999 - europepmc.org
Normal immune surveillance depends on the ability of MHC class II molecules to bind
peptide antigens and carry them to the cell surface for display to T cells. To do this efficiently …
peptide antigens and carry them to the cell surface for display to T cells. To do this efficiently …
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding
GJ Carven, S Chitta, I Hilgert, MM Rushe… - Journal of Biological …, 2004 - ASBMB
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at
the cell surface for interaction with CD4+ T cells as part of the system by which the immune …
the cell surface for interaction with CD4+ T cells as part of the system by which the immune …
Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.
JM Riberdy, RR Avva, HJ Geuze… - The Journal of cell …, 1994 - rupress.org
We have compared the intracellular transport and subcellular distribution of MHC class II-
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation
JL Fallas, HM Tobin, O Lou, D Guo… - The Journal of …, 2004 - journals.aai.org
The MHC class II-like molecule HLA-DM (DM)(H-2M in mice) catalyzes the exchange of
CLIP for antigenic peptides in the endosomes of APCs. HLA-DO (DO)(H-2O in mice) is …
CLIP for antigenic peptides in the endosomes of APCs. HLA-DO (DO)(H-2O in mice) is …
Self and foreign peptides interact with intact and disassembled MHC class II antigen HLA-DR via tryptophan pockets
H Kropshofer, I Bohlinger, H Max, H Kalbacher - Biochemistry, 1991 - ACS Publications
FRG Received April 12, 1991; Revised Manuscript Received June 18, 1991 abstract: The
acid release of endogenous peptides from immunoaffinity-pure human major histocom …
acid release of endogenous peptides from immunoaffinity-pure human major histocom …
Substitution of aspartic acid at β57 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (α1∗ 0201, β1∗ 0302) and (α1∗ 0201, β1 …
In class II major histocompatibility complex (MHC) proteins, residue β57 is usually aspartic
acid. Alleles carrying serine, valine, or alanine at this position are strongly correlated with …
acid. Alleles carrying serine, valine, or alanine at this position are strongly correlated with …
Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.
T Monji, AL McCormack, JR Yates 3rd… - Journal of immunology …, 1994 - journals.aai.org
Class II presentation mutants have mutations in the HLA-DMA or B genes and are defective
in the presentation of whole exogenous Ags restricted by HLA-DR,-DQ, and-DP. The …
in the presentation of whole exogenous Ags restricted by HLA-DR,-DQ, and-DP. The …
DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
MA Sherman, DA Weber, PE Jensen - Immunity, 1995 - cell.com
Major histocompatibllity complex (MHC) class II molecules bind antigenic peptides rapidly
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …
Peptide binding to HLA‐DR1: a peptide with most residues substituted to alanine retains MHC binding.
TS Jardetzky, JC Gorga, R Busch, J Rothbard… - The EMBO …, 1990 - embopress.org
Major histocompatibility complex (MHC) glycoproteins play an important role in the
development of an effective immune response. An important MHC function is the ability to …
development of an effective immune response. An important MHC function is the ability to …