HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …

Peptide binding to classical major histocompatibility complex (MHC) class II molecules is
known to be determined by the properties of the class ii peptide binding groove but recently …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

MHC class II molecules usually bind peptides in the endocytic pathway, but can also present
endogenous peptides from newly synthesized proteins in a chloroquine‐insensitive manner …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

To investigate a conformational change accompanying peptide binding to class II MHC
proteins, we probed the structure of a soluble version of the human class II MHC protein HLA …

THE invariant chain, which associates with the major histocompatibility complex (MHC)
class II molecules in the endoplasmic reticulum, serves two functions important in antigen …

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its
mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA …

Background: Class II major histocompatibility complex (MHC) proteins are cell surface
glycoproteins that bind peptides and present them to T cells as part of the mechanism for …

Classical human leukocyte antigen (HLA) molecules of the major histocompatibility class II
(MHCII) complex present peptides for the development, surveillance and activation of CD4+ …