MHC class II molecules (MHC II) play a pivotal role in the cell-surface presentation of
antigens for surveillance by T cells. Antigen loading takes place inside the cell in endosomal …

T cells generally recognize peptide antigens bound to MHC proteins through contacts with
residues found within or immediately flanking the seven-to nine-residue sequence …

Certain HLA-DR alleles confer strong susceptibility to the autoimmune disease rheumatoid
arthritis (RA). We compared RA-associated alleles, HLA-DR* 0401, HLA-DR* 0404, and …

CLASS II major histocompatibility complex (MHC) molecules are heterodimeric cell surface
glycoproteins which bind and present immunogenic peptides to T lymphocytes. Such …

A fundamental characteristic of MHC class I and class II proteins is their unusual capacity to
form stable complexes with a wide spectrum of peptide ligands. In this study, sets of peptide …

Recent studies have revealed that the conserved major histocompatibility complex class II
molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in …

Position 57 in the beta chain of HLA class II molecules maintains an Asp/non-Asp
dimorphism that has been conserved through evolution and is implicated in susceptibility to …

Ag presentation by MHC class II (MHC II) molecules to CD4+ T cells plays a key role in the
regulation of the adaptive immune response. Loading of antigenic peptides onto MHC II is …

The HLA-DM genes encode an unconventional HLA (human leukocyte antigen) class II
molecule that is required for appropriate binding of peptide to classical HLA class II …

The assembly and transport of major histocompatibility complex (MHC) class II molecules
require interaction with the invariant chain. A fragment of the invariant chain, CLIP, occupies …