Abstract Learning Objectives After completing this course, the reader will be able to:
Compare and contrast the mechanism of action for angiogenesis inhibitors currently being …

Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a central
role in the process of tumor growth and metastasis. The proliferation of endothelium and …

Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of
new vessels is crucial to provide malignant cells with an adequate supply of oxygen and …

New blood vessel formation (angiogenesis) is fundamental to the process of tumor growth,
invasion, and metastatic dissemination. The vascular endothelial growth factor (VEGF) …

Angiogenesis, the formation of blood vessels, is essential for preparing a closed circulatory
system in the body, and for supplying oxygen and nutrition to tissues. Major diseases such …

In 1966, Folkman et al first theorized that tumor growth beyond 1 to 2 mm3 depends on a
process called angiogenesis—the development of new tumorassociated blood vessels that …

Several new agents that target the vascular endothelial growth factor (VEGF) pathway and
inhibit angiogenesis are emerging as promising therapies in multiple cancer types …

Angiogenesis and vasculogenesis, regulated by VEGF/VEGFR signaling pathways, play key
roles in tumor growth and metastasis. Selective inhibition of VEGFR kinase has been …

Angiogenesis is required for tumor growth and metastasis and, therefore, represents an
exciting target for cancer treatment. Angiogenesis is a complex process that is tightly …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …