Plasticity in the injured spinal cord: can we use it to advantage to reestablish effective bladder voiding and continence?

NDT Zinck, JW Downie - Progress in Brain Research, 2006 - Elsevier
Micturition is coordinated at the level of the spinal cord and the brainstem. Spinal cord injury
therefore directly interrupts spinal neuronal pathways to the brainstem and results in bladder …

Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury

WC de Groat, N Yoshimura - Progress in brain research, 2006 - Elsevier
The lower urinary tract has two main functions, the storage and periodic expulsion of urine,
which are regulated by a complex neural control system in the brain and lumbosacral spinal …

Plasticity in reflex pathways to the lower urinary tract following spinal cord injury

WC de Groat, N Yoshimura - Experimental neurology, 2012 - Elsevier
The lower urinary tract has two main functions, storage and periodic expulsion of urine, that
are regulated by a complex neural control system in the brain and lumbosacral spinal cord …

Changes in afferent activity after spinal cord injury

WC de Groat, N Yoshimura - Neurourology and Urodynamics …, 2010 - Wiley Online Library
Aims To summarize the changes that occur in the properties of bladder afferent neurons
following spinal cord injury. Methods Literature review of anatomical, immunohistochemical …

Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury

MA Vizzard - Progress in brain research, 2006 - Elsevier
Transection of the spinal cord that interrupts the spinobulbospinal micturition reflex pathway,
abolishes voluntary voiding and initially produces an areflexic bladder with complete urinary …

Bladder afferent pathway and spinal cord injury: possible mechanisms inducing hyperreflexia of the urinary bladder

N Yoshimura - Progress in neurobiology, 1999 - Elsevier
Lower urinary tract dysfunction is a common problem in patients with spinal cord injury (SCI).
Since the coordination of the urinary bladder and urethra is controlled by the complex …

Sprouting of CGRP primary afferents in lumbosacral spinal cord precedes emergence of bladder activity after spinal injury

NDT Zinck, VF Rafuse, JW Downie - Experimental neurology, 2007 - Elsevier
Spinal cord injury (SCI) severely disrupts bladder function. What mediates bladder
dysfunction after SCI is currently unknown. We investigated the role that primary afferent …

[HTML][HTML] Slow development of bladder malfunction parallels spinal cord fiber sprouting and interneurons' loss after spinal cord transection

AM Sartori, AS Hofer, MI Scheuber, R Rust… - Experimental …, 2022 - Elsevier
Neurogenic lower urinary tract dysfunction typically develops after spinal cord injury. We
investigated the time course and the anatomical changes in the spinal cord that may be …

Pharmacologic and potential biologic interventions to restore bladder function after spinal cord injury

N Yoshimura, CP Smith, MB Chancellor… - Current opinion in …, 2000 - journals.lww.com
Spinal cord injury disrupts voluntary control of voiding and the normal reflex pathways that
coordinate bladder and urethral sphincter function. The present review addresses studies in …

Coordination of the bladder detrusor and the external urethral sphincter in a rat model of spinal cord injury: effect of injury severity

V Pikov, JR Wrathall - Journal of Neuroscience, 2001 - Soc Neuroscience
Recovery of urinary tract function after spinal cord injury (SCI) is important in its own right
and may also serve as a model for studying mechanisms of functional recovery after injury in …