Vascular endothelial-cadherin and vascular stability

E Dejana, C Giampietro - Current opinion in hematology, 2012 - journals.lww.com
In the past years, the research on angiogenesis was mostly directed to the definition of the
mechanisms able to modulate vascular growth. We now understand that in many …

Structural and functional studies of full-length vascular cell adhesion molecule-1: internal duplication and homology to several adhesion proteins

TOM POLTE, W NEWMAN, G Raghunathan… - DNA and cell …, 1991 - liebertpub.com
Full-length vascular cell adhesion molecule-1 (VCAM-1) cDNA cloned by polymerase chain
reaction (PCR) of poly (A)+ RNA from interleukin-1 (IL-l)-activated human umbilical vein …

VE-cadherin: at the front, center, and sides of endothelial cell organization and function

ES Harris, WJ Nelson - Current opinion in cell biology, 2010 - Elsevier
Endothelial cells form cell–cell adhesive structures, called adherens and tight junctions,
which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the …

A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter Alters Transcriptional Activities

LC Li, RM Chui, M Sasaki, K Nakajima, G Perinchery… - Cancer research, 2000 - AACR
E-cadherin plays a critical role in many aspects of cell adhesion, epithelial development,
and the establishment and maintenance of epithelial polarity. The loss of the adhesive …

[HTML][HTML] Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

F Orsenigo, C Giampietro, A Ferrari, M Corada… - Nature …, 2012 - nature.com
Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their
permeability but whether organization and strength of their adherens junctions vary has not …

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

D Riethmacher, V Brinkmann… - Proceedings of the …, 1995 - National Acad Sciences
The Ca (2+)-dependent cell adhesion molecule E-cadherin functions in the establishment
and maintenance of epithelial cell morphology during embryogenesis and adulthood …

Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter

D Lopez, G Niu, P Huber, WB Carter - Archives of biochemistry and …, 2009 - Elsevier
Endothelial integrity is dependent on intracellular adherens junctions formed by complexes
of vascular endothelial (VE)-cadherin and catenins. We have previously demonstrated that …

An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation

A Ferber, C Yaen, E Sarmiento, J Martinez - Experimental cell research, 2002 - Elsevier
The cadherins are a family of adhesive proteins involved in cell-cell homophilic interactions.
VE-cadherin, expressed in endothelial cells, is involved in morphogenesis, regulation of …

Vascular endothelial (VE)-cadherin, endothelial adherens junctions, and vascular disease

MG Lampugnani, E Dejana… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Endothelial cell–cell adherens junctions (AJs) supervise fundamental vascular functions,
such as the control of permeability and transmigration of circulating leukocytes, and the …

[HTML][HTML] VE-cadherin endocytosis controls vascular integrity and patterning during development

CM Grimsley-Myers, RH Isaacson, CM Cadwell… - Journal of Cell …, 2020 - rupress.org
Tissue morphogenesis requires dynamic intercellular contacts that are subsequently
stabilized as tissues mature. The mechanisms governing these competing adhesive …