Understanding gene expression profiles during early human pancreas development is
limited by comparison to studies in rodents. In this study, from the inception of pancreatic …

Aims/hypothesis Morphological changes that occur during pancreatic endocrine cell
differentiation have been shown in rodent systems to be dependent on sequential …

Introduction β-cell regeneration is an area under active investigation for the future treatment
of diabetes, but little is known about the patterns and dynamics of prenatal β-cell …

Aims/hypothesis An immunohistochemical and genomic analysis of human pancreatic
development from 9–23 weeks of fetal age was undertaken to provide a comparative …

Lineage tracing follows the progeny of labeled cells through development. This technique
identifies precursors of mature cell types in vivo and describes the cell fate restriction steps …

Knowledge of human pancreas development underpins our interpretation and exploitation
of human pluripotent stem cell (PSC) differentiation toward a β-cell fate. However, almost no …

Low birth weight is an important risk factor for type 2 diabetes in later life. Maturity-onset
diabetes of the young has been linked to genetic sequence abnormalities in transcription …

In recent years major progress has been made in understanding the role of transcription
factors in the development of the endocrine pancreas in the mouse. Here we describe how a …

Considerable knowledge of the ontogeny of the endocrine pancreas has been gained in
recent years, mainly through the use of two complementary genetic approaches in …

The importance of mesenchymal-epithelial interactions for normal development of the
pancreas was recognized in the early 1960s, and mesenchymal signals have been shown …