Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease

SF van Eeden, A Yeung, K Quinlam… - Proceedings of the …, 2005 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a risk factor for development of
cardiovascular events, independent of smoking. The mechanisms are unclear, but systemic …

Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants

K Hiraiwa, SF van Eeden - Mediators of inflammation, 2013 - Wiley Online Library
Large population cohort studies have indicated an association between exposure to
particulate matter and cardiopulmonary morbidity and mortality. The inhalation of toxic …

Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation

SF Eeden, JC Hogg - … of Toxicology and Environmental Health, Part …, 2002 - Taylor & Francis
The relationship between the level of particulate air pollution (PM 10) and the mortality and
morbidity rates from respiratory and cardiovascular diseases is well established, but the …

Pulmonary and systemic response to atmospheric pollution

JC Hogg, S Van Eeden - Respirology, 2009 - Wiley Online Library
The inhalation of toxic particles and gases reduces the innate defences of the lung by
increasing epithelial permeability, decreasing mucociliary clearance and depressing …

Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature

G Grunig, LM Marsh, N Esmaeil… - Pulmonary …, 2014 - journals.sagepub.com
Particulates from air pollution are implicated in causing or exacerbating respiratory and
systemic cardiovascular diseases and are thought to be among the leading causes of …

Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease

T Sint, JF Donohue, AJ Ghio - Inhalation toxicology, 2008 - Taylor & Francis
Investigation has repeatedly demonstrated an association between exposure to ambient air
pollution particles and numerous indices of human morbidity and mortality. Individuals with …

Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction

E Tamagawa, N Bai, K Morimoto… - … of Physiology-Lung …, 2008 - journals.physiology.org
Epidemiologic and animal studies have shown that exposure to particulate matter air
pollution (PM) is a risk factor for the development of atherosclerosis. Whether PM-induced …

Reactive oxygen species in pulmonary inflammation by ambient particulates

F Tao, B Gonzalez-Flecha, L Kobzik - Free Radical Biology and Medicine, 2003 - Elsevier
Exposure to ambient air pollution particles (PM) has been associated with increased
cardiopulmonary morbidity and mortality, particularly in individuals with pre-existing disease …

Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease

SH Ling, SF van Eeden - International journal of chronic …, 2009 - Taylor & Francis
Due to the rapid urbanization of the world population, a better understanding of the
detrimental effects of exposure to urban air pollution on chronic lung disease is necessary …

Particulate matter induces translocation of IL-6 from the lung to the systemic circulation

T Kido, E Tamagawa, N Bai, K Suda… - American journal of …, 2011 - atsjournals.org
The biological mechanisms responsible for an association between elevated concentrations
of ambient particulate matter (PM) and increased cardiovascular morbidity and mortality …