Comparison between in situ hybridization and real-time PCR technique as a means of detecting the integrated form of human papillomavirus 16 in cervical neoplasia

T Fujii, N Masumoto, M Saito, N Hirao… - Diagnostic Molecular …, 2005 - journals.lww.com
Integration of the human papillomavirus (HPV) genome is thought to be one of the causes of
cancer progression. However, there is controversy concerning the physical status of HPV 16 …

Physical state of HPV16 and chromosomal mapping of the integrated form in cervical carcinomas

M Kalantari, E Blennow, B Hagmar… - Diagnostic Molecular …, 2001 - journals.lww.com
Using a procedure based on restriction enzyme cleavage, self-ligation, and inverse
polymerase chain reaction (rli PCR), the authors investigated 18 cervical intraepithelial …

Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique

P Peitsaro, B Johansson… - Journal of clinical …, 2002 - Am Soc Microbiol
In contrast to cervical cancer, integration of human papillomavirus (HPV) DNA into the host
genome has been considered a rare event in cancer precursor lesions (cervical …

Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer

H Arias-Pulido, CL Peyton, NE Joste… - Journal of clinical …, 2006 - Am Soc Microbiol
Integration of human papillomavirus type 16 (HPV-16) into the host DNA has been proposed
as a potential marker of cervical neoplastic progression. In this study, a quantitative real-time …

Integration of human papillomavirus type-16 and type-18 is a very early event in cervical carcinogenesis

LW Huang, SL Chao, BH Lee - Journal of clinical pathology, 2008 - jcp.bmj.com
Aim: Human papillomavirus (HPV) integration is a critical event in cervical carcinogenesis.
The aim of this study was to explore the physical status of HPV-16 and HPV-18 during the …

Definition of human papillomavirus type 16 DNA levels in low and high grade cervical lesions by a simple polymerase chain reaction technique

G Terry, L Ho, D Jenkins, M Hills, A Singer, B Mansell… - Archives of …, 1993 - Springer
Summary Human papillomavirus type 16 (HPV 16) is associated with a high proportion of
cervical cancers and pre-cancers but has also been reported by some workers to be widely …

Real-time PCR-based system for simultaneous quantification of human papillomavirus types associated with high risk of cervical cancer

M Moberg, I Gustavsson… - Journal of clinical …, 2003 - Am Soc Microbiol
We have previously shown that women with a high titer of human papillomavirus type 16
(HPV16) in cervical epithelial cells have an increased risk of developing cervical carcinoma …

Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR

S Nagao, M Yoshinouchi, Y Miyagi… - Journal of clinical …, 2002 - Am Soc Microbiol
ABSTRACT A rapid quantitative real-time PCR method was employed to quantify the copy
number of E2 and E6 genes for analysis of the physical status of human papillomavirus type …

Detection of human papillomavirus type 16 integration in pre-neoplastic cervical lesions and confirmation by DIPS-PCR and sequencing

L De Marco, A Gillio-Tos, L Bonello, V Ghisetti… - Journal of clinical …, 2007 - Elsevier
BACKGROUND: Persistent infections with high-risk types of human papillomavirus (HR-
HPV) favour integration of viral DNA into the host cells and are associated with cervical …

Analysis by polymerase chain reaction of the physical state of human papillomavirus type 16 DNA in cervical preneoplastic and neoplastic lesions

BC Das, JK Sharma… - Journal of General …, 1992 - microbiologyresearch.org
Integration of human papillomavirus (HPV) DNA into the host cell genome is believed to be
essential for malignant progression. However unambiguous detection of the physical state of …