Background Drug use disorders are an increasing cause of disability and early death in the
USA, with substantial geographical variation. We aimed to investigate the associations …

The impact of rising drug use on US mortality may extend beyond deaths coded as drug-
related to include excess mortality from other causes affected by drug use. Here, we …

Background Increasing premature mortality among some groups of Americans has been
largely driven by increases in drug poisoning deaths. However, to our knowledge, a formal …

This study examines the contributions of the medium-run evolution of local economies and
of changes in the “drug environment'in explaining county-level changes in drug and related …

Importance Life expectancy has decreased in the US, driven largely by increases in drug
poisoning, suicide, and alcohol-induced deaths. Assessing whether patterns of these …

Background The USA ranks last in life expectancy among high-income countries. Since
2000, excess US mortality has been particularly concentrated in the working ages, which are …

Drug-related mortality in the US grew dramatically in recent years, while mental health
deteriorated among disadvantaged Americans and reported levels of pain increased over …

We examine the effects of state-level economic conditions including unemployment rates,
median house price, median household income, insurance coverage, and annual and …

Abstract Introduction The Global Burden of Disease (GBD) 2010 study updated the findings
of earlier exercises. It provided regional and global estimates of the burden of disease …

Background Disorders affecting mental health are highly prevalent, can be disabling, and
are associated with substantial premature mortality. Yet national health system responses …