Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk
receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor …

Neurotrophins influence growth and survival of specific populations of neurons through
activation of Trks, members of the receptor tyrosine kinase (RTK) family. In this report, we …

Neurotrophins and their Trk receptors play a crucial role in the development and
maintenance of the vertebrate nervous system, but to date no component of this signalling …

The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …

The trkC gene product gp145trkC is a high affinity signaling receptor for neurotrophin‐3 (NT‐
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …

trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of …

We have investigated the molecular nature of the high affinity nerve growth factor (NGF)
receptors by using cell lines expressing gp75 LNGFR and gp140 trk Our results suggest that …

Endocytic trafficking of signaling receptors to alternate intracellular pathways has been
shown to lead to diverse biological consequences. In this study, we report that two …

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related
neurotrophins. Here we present a developmental expression study of trk C, which encodes a …