The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the
effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The …

Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction.
Recently, other roles for these receptors have been identified. Many questions have been …

Neurotrophins are critical for the development and maintenance of the peripheral and
central nervous system. These highly homologous, homodimeric growth factors control cell …

We have previously described the expression of a functional full‐length trkC transcript for
neurotrophin‐3 (NT‐3) receptor in oligodendroglia (OL) cells (Kumar and de Vellis, 1996) …

Neurons of the peripheral nervous system have long been known to require survival factors
to prevent their death during development. But why they selectively become dependent on …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by
binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk …

Neurotrophins influence growth and survival of sympathetic and sensory neurons through
activation of their receptors, Trk receptor tyrosine kinases. Previously, we identified Src …

In neurons, long-distance communication between axon terminals and cell bodies is a
critical determinant in establishing and maintaining neural circuits. Neurotrophins are …

This review focuses on recent advances in our understanding of receptor-mediated
signaling by the neurotrophins NGF, BDNF, NT3, and NT4/5. Two distinct receptor types …