The TrkA receptor is activated primarily by nerve growth factor (NGF), but it can also be
activated by high concentrations of neurotrophin 3 (NT-3). The pan-neurotrophin receptor …

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75
neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of …

Neurotrophins and their receptors are frequently expressed in malignant gliomas, yet their
functions are largely unknown. Previously, we have shown that p75 neurotrophin receptor is …

We have examined whether the low affinity neurotrophin receptor p75NTR modulates TrkA
function by intracellular signaling. Using ligands that selectively bind p75NTR or TrkA, we …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons, and have since been shown to control a …

Specificity of neurotrophin factor signaling is dictated through the action of Trk receptor
tyrosine kinases. Once activated, Trk receptors are internalized and targeted for …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

To investigate the role of the gp140trk receptor tyrosine kinase in nerve growth factor (NCF)-
induced differentiation, we have overexpressed gp140* & in the NGF-responsive PC12 cell …

Spinal sensory ganglia have been shown to contain neuronal subpopulations with different
functions and neurotrophin dependencies. Neurotrophins act, in large part, through Trk …

The mammalian trkC gene encodes a tyrosine protein kinase that serves as a functional
receptor for neurotrophin-3 (NT-3). Here, we report that trkC is widely expressed in the …