AMIODARONE, an iodine-containing benzofuran derivative, has been widely available in
Europe for over 15 years, but its use in North America is still experimental. The drug has …

Amiodarone has been reported to cause asymptomatic increases in liver function tests in 15—
55% of patients. Clinically apparent, symptomatic hepatic disease occurs less frequently, but …

Amiodarone is a class III antiarrhythmic drug widely used for the treatment of both
supraventricular and ventricular arrhythmias in intensive care unit. Hepatotoxicity of …

The prevalence of apparent amiodarone-related hepatic injury in 104 patients followed
prospectively is compared to that reported in the literature. Asymptomatic elevation of serum …

This analysis of the morphology of suspected amiodarone (AD) liver disease is based on a
study of liver specimens from 17 individuals. Changes similar to alcoholic liver injury were …

Excerpt Amiodarone, a benzofuran derivative structurally related to thyroxine, has been
used to treat heart disease for 25 years. It is an amphophilic compound that may induce …

Amiodarone was used to treat cardiac arrhythmias that had been refractory to conventional
medical therapy. The first 70 consecutive patients treated with amiodarone in this study had …

Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …

A 63-year-old man presented with ascites after therapy with amiodarone, 200 mg orally once
per day for 22.5 months. A liver biopsy showed grade 3 chronic hepatitis and micronodular …

Five patients had amiodarone hepatotoxicity detected on routine biochemical monitoring.
Symptoms attributable to hepatotoxicity were minimal or absent; reversible hepatomegaly …