OBJECTIVE: To determine first-trimester fetal sex by isolating free fetal DNA from maternal
plasma. METHODS: The index case was a pregnant woman who previously delivered a girl …

Circulating fetal DNA in maternal plasma and serum was first demonstrated by Lo et al. in
1997 and has become a useful tool for prenatal diagnosis less than five years later. There is …

Objective Since the discovery of cell‐free fetal DNA (cffDNA) in maternal plasma, diagnostic
non‐invasive prenatal methods have been developed or optimized for fetal sex …

Objective. The detection of paternally inherited sequences in maternal plasma, such as the
SRY gene for fetal sexing or RHD for fetal blood group genotyping, is becoming part of daily …

Objectives We have determined the number of fetal nucleated cells and the concentration of
cell‐free fetal DNA in parallel in the same maternal blood samples either before or after …

A new method of prenatal sex determination, based on identification of “Y body” or the male
sex chromosome, is introduced. The Y-chromosome is detected in interphase nuclei of …

We have prospectively examined the diagnostic accuracy of a conventional multiplex
polymerase chain reaction (PCR) analysis of maternal plasma for fetal gender determination …

Objectives To test the distribution of fetal DNA in maternal plasma expressed as gen/eq in a
population of normal pregnancies. Methods Peripheral blood samples were obtained from …

Cell-free fetal DNA can be detected in the blood plasma of pregnant women as early as 5 wk
into pregnancy. At present noninvasive prenatal diagnosis has already begun to impact …

We have investigated the use of a nested polymerase chain reaction assay for the detection
of a fetal-specific Y-chromosomal sequence (DYS14) from DNA extracted from unsorted …