[HTML][HTML] Linking Cellular Morphogenesis with Antifungal Treatment and Susceptibility in Candida Pathogens

J Sharma, S Rosiana, I Razzaq, RS Shapiro - Journal of Fungi, 2019 - mdpi.com
Fungal infections are a growing public health concern, and an increasingly important cause
of human mortality, with Candida species being amongst the most frequently encountered of …

Candida morphogenesis and host–pathogen interactions

M Whiteway, U Oberholzer - Current opinion in microbiology, 2004 - Elsevier
The human fungal pathogen Candida albicans has many morphological forms. Recent
advances in genomics and cell biology are providing an improved understanding of the …

Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans

D Kadosh - Current opinion in microbiology, 2019 - Elsevier
Highlights•There is a strong association between C. albicans morphology and virulence.•C.
albicans morphology control mechanisms may serve as important antifungal …

Coevolution of morphology and virulence in Candida species

DS Thompson, PL Carlisle, D Kadosh - Eukaryotic cell, 2011 - Am Soc Microbiol
Many of the major human fungal pathogens are known to undergo morphological changes,
which in certain cases are associated with virulence. Although there has been an intense …

[HTML][HTML] The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

D Wilson, JR Naglik, B Hube - PLoS pathogens, 2016 - journals.plos.org
Fungal pathogens are more commonly associated with morbidity and mortality than
generally appreciated. In fact, a significant portion of the world population is infected by …

The regulation of hyphae growth in Candida albicans

H Chen, X Zhou, B Ren, L Cheng - Virulence, 2020 - Taylor & Francis
In the last decades, Candida albicans has served as the leading causal agent of life-
threatening invasive infections with mortality rates approaching 40% despite treatment …

Potential targets for antifungal drug discovery based on growth and virulence in Candida albicans

X Li, Y Hou, L Yue, S Liu, J Du… - Antimicrobial agents and …, 2015 - Am Soc Microbiol
Fungal infections, especially infections caused by Candida albicans, remain a challenging
problem in clinical settings. Despite the development of more-effective antifungal drugs, their …

Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges

PP de Barros, RD Rossoni, CM de Souza, L Scorzoni… - Mycopathologia, 2020 - Springer
Fungi of the genus Candida are important etiological agents of superficial and life-
threatening infections in individuals with a compromised immune system. One of the main …

[HTML][HTML] Recent advances in understanding Candida albicans hyphal growth

RA Arkowitz, M Bassilana - F1000Research, 2019 - ncbi.nlm.nih.gov
Morphological changes are critical for the virulence of a range of plant and human fungal
pathogens. Candida albicans is a major human fungal pathogen whose ability to switch …

Targeting Candida albicans filamentation for antifungal drug development

T Vila, JA Romo, CG Pierce, SF McHardy, SP Saville… - Virulence, 2017 - Taylor & Francis
Candida albicans remains the main etiological agent of candidiasis, as this otherwise
normal commensal of humans is capable of causing active infection in immune-and …