Objective: To investigate the effect of Shaoyao Gancao Decoction (SGD) on the
pharmacokinetics of intravenously administered paclitaxel in rats. Methods: Paclitaxel was …

Paclitaxel is a natural terpenoid compound with anti-cancer activity. It is one of the
chemotherapeutic agents used in treatment of solid tumours. In cancer patients, the use of …

The aim of this study was to investigate the effect of naringin on the bioavailability and
pharmacokinetics of paclitaxel after oral administration of paclitaxel or its prodrug …

The purpose of this study was to investigate the effect of coadministration (2.5, 10, 20 mg/kg)
and 3 or 7 days-pretreatment (10 mg/kg) of diltiazem on the pharmacokinetic parameters of …

The purpose of this study was to investigate the effect of verapamil on the pharmacokinetic
parameters of paclitaxel (50mg/kg) when paclitaxel is co-administered with verapamil (1, 5 …

Paclitaxel is a substrate of the efflux transporters such as P‐glycoprotein, and is mainly
metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra …

Wuzhi tablet (WZ, registration no. in China: Z20025766) is a preparation of an ethanol herb
extract of Wuweizi (Schisandra sphenanthera) containing 7.5 mg Schisantherin A per tablet …

As many anticancer agents paclitaxel is a substrate for ATP-binding cassette (ABC)
transporters such as P-glycoprotein-mediated efflux, and its metabolism in humans mainly …

Objective: To establish an RP-HPLC method for the determination concentration of
paclitaxel in serum and tissues in mice. Methods: The Intertex C18 column (150 mm× 4.6 …

The purpose of this study was to investigate the effect of a cotreatment of bamboo
concentrates (Jukcho solution; 0.75, 1.5, and 3.0 mL/kg) with the chemotherapeutic agent …