Abnormalities of regulatory T cells may play an important role in the loss of self-tolerance,
which is a major characteristic of lupus. The objective of this study was to determine the ratio …

CD4+ T cells that constitutively express CD25 exhibit powerful suppressive properties. Such
cells have been denominated regulatory T cells (TR). Alterations in TRcells are known to …

Regulatory T cells (Tregs) are supposed to stop immune responses in the course of immune
activation. However, chronic activation of immune system in systemic lupus erythematosus …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by
increased pathologic autoantibody production. A decrease in the number of CD4+ …

The available clinical as well as experimental studies implicate participation of T regulatory
(Treg) subsets in the pathogenesis and course of systemic lupus erythematosus (SLE) …

Recent studies show that a CD8+ CD28− phenotype of T-cell population inhibits the
reactivity of T-helper cells either by a contact-dependent mechanism or with secreting …

Methods Tregs (CD4+CD25highFOXP3+) were prospectively assessed by flow cytometry in
285 separate blood samples from 100 white Caucasian SLE patients and 20 healthy …

Objectives: Regulatory T cells (Tregs) are inversely correlated to disease activity in systemic
lupus erythematosus (SLE). However, little is known concerning the influence of …

Abstract CD4+ CD25+ Foxp3+ regulatory T cells (Treg) that specialize in the suppression of
immune responses might be critically involved in the pathogenesis of autoimmune diseases …

Background. Accumulating evidence indicates that a deficiency in or dysfunction of
regulatory T cells (Tregs) is involved in the pathogenesis of systemic lupus erythematosus …