Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-
negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling …

Yersinia pestis, the causative agent of plague, secretes LcrV (low-calcium-response V or V
antigen) during infection. LcrV triggers the release of interleukin 10 (IL-10) by host immune …

Yersinia pestis, the etiologic agent of plague, secretes a set of environmentally regulated,
plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III …

Yersinia pestis is the causative agent of plague. Previously we have isolated an attenuated
Y. pestis transposon insertion mutant in which the pcm gene was disrupted. In the present …

Yersinia pestis is a facultative intracellular bacterial pathogen that can replicate in
macrophages. Little is known about the mechanism by which Y. pestis replicates in …

Inhalation of Yersinia pestis causes primary pneumonic plague, a highly lethal syndrome
with mortality rates approaching 100%. Pneumonic plague progression is biphasic, with an …

Yersinia murine toxin (Ymt) is a phospholipase D encoded on a plasmid acquired by
Yersinia pestis after its recent divergence from a Yersinia pseudotuberculosis progenitor …

A chromosomally encoded protein, which mediates invasion into HeLa cells was recently
identified in Yersinia pseudotuberculosis 1, 2. The role of this protein (invasin) in the …

The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject
effector Yop proteins into host cells via the type III pathway. The identity of the host cells …

There is an urgent need to develop effective vaccines against pneumonic plague, a highly
lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here …