Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malaria

M Gendrot, R Fawaz, J Dormoi, M Madamet… - Clinical Microbiology …, 2019 - Elsevier
Background PfHRP2-based rapid diagnostic tests (RDTs), based on the recognition of the
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …

Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana

LE Amoah, J Abankwa, A Oppong - Malaria journal, 2016 - Springer
Background Malaria rapid diagnostic tests (RDTs) play a key role in malaria management
and control. The PfHRP-2 based RDT is the most widely used RDT for malaria diagnosis in …

Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from Mozambique

H Gupta, G Matambisso, B Galatas, P Cisteró… - Malaria journal, 2017 - Springer
Abstract Background Malaria programmes use Plasmodium falciparum histidine-rich protein-
2 (PfHRP2) based rapid diagnostic tests (RDTs) for malaria diagnosis. The deletion of this …

Histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in Plasmodium falciparum isolates from select sites in Brazil and Bolivia

GM Rachid Viana, S Akinyi Okoth, L Silva-Flannery… - PloS one, 2017 - journals.plos.org
More than 80% of available malaria rapid diagnostic tests (RDTs) are based on the
detection of histidine-rich protein-2 (PfHRP2) for diagnosis of Plasmodium falciparum …

Streamlined, PCR-based testing for pfhrp2- and pfhrp3-negative Plasmodium falciparum

JB Parr, O Anderson, JJ Juliano, SR Meshnick - Malaria journal, 2018 - Springer
Abstract Background Rapid diagnostic tests (RDTs) that detect histidine-rich protein 2
(PfHRP2) are used throughout Africa for the diagnosis of Plasmodium falciparum malaria …

Variation in Plasmodium falciparum Histidine-Rich Protein 2 (Pfhrp2) and Plasmodium falciparum Histidine-Rich Protein 3 (Pfhrp3) Gene Deletions in Guyana and …

S Akinyi Okoth, JF Abdallah, N Ceron, MR Adhin… - PLoS …, 2015 - journals.plos.org
Guyana and Suriname have made important progress in reducing the burden of malaria.
While both countries use microscopy as the primary tool for clinical diagnosis, malaria rapid …

Genetic Diversity of Plasmodium falciparum Histidine-Rich Protein 2 (PfHRP2) and Its Effect on the Performance of PfHRP2-Based Rapid Diagnostic Tests

J Baker, J McCarthy, M Gatton, DE Kyle… - The Journal of …, 2005 - academic.oup.com
Rising costs of antimalarial agents are increasing the demand for accurate diagnosis of
malaria. Rapid diagnostic tests (RDTs) offer great potential to improve the diagnosis of …

Identification of Plasmodium falciparum isolates lacking histidine-rich protein 2 and 3 in Eritrea

M Menegon, M L'Episcopia, AM Nurahmed… - Infection, Genetics and …, 2017 - Elsevier
The histidine-rich protein 2 of Plasmodium falciparum is the most common malaria antigen
targeted by rapid diagnostic tests for the specific diagnosis of P. falciparum. Recently, pfhrp2 …

pfhrp2 and pfhrp3 Gene Deletions That Affect Malaria Rapid Diagnostic Tests for Plasmodium falciparum: Analysis of Archived Blood Samples From 3 African …

R Thomson, KB Beshir, J Cunningham… - The Journal of …, 2019 - academic.oup.com
Background Malaria rapid diagnostic tests (mRDTs) that target histidine-rich protein 2
(HRP2) are important tools for Plasmodium falciparum diagnosis. Parasites with pfhrp2/3 …

Prevalence of pfhrp2 and/or pfhrp3 Gene Deletion in Plasmodium falciparum Population in Eight Highly Endemic States in India

PK Bharti, HS Chandel, A Ahmad, S Krishna… - PloS one, 2016 - journals.plos.org
Background Plasmodium falciparum encoded histidine rich protein (HRP2) based malaria
rapid diagnostic tests (RDTs) are used in India. Deletion of pfhrp2 and pfhrp3 genes …