Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …

Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces
numerous adverse effects. The most critical of these is pulmonary toxicity because of the …

The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …

The distribution of the antiarrhythmic drug amiodarone and its principal lipophilic metabolite,
desethylamiodarone, was determined in postmortem tissues of six patients who received …

The effectiveness of amiodarone in the treatment of cardiac arrhythmias is limited due to the
development of pulmonary toxicity. Although the biochemical and morphologic …