Amiodarone pulmonary toxicity: morphologic and biochemical features
MJ Reasor, S Kacew - Proceedings of the Society for …, 1991 - journals.sagepub.com
Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …
underlying serious adverse effects remain to be resolved and still limit drug usefulness …
Mechanisms of amiodarone pulmonary toxicity
WJ Martin II - Clinics in chest medicine, 1990 - Elsevier
Amiodarone pulmonary toxicity is one of the most important examples of drug-induced lung
disease by non-cancer chemotherapeutic agents. Current concepts suggest that patients …
disease by non-cancer chemotherapeutic agents. Current concepts suggest that patients …
Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster
E Rafeiro, RG Leeder, JF Brien, GW Kabalka… - Toxicology and applied …, 1994 - Elsevier
Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells
FC Roth, JE Mulder, JF Brien, T Takahashi… - Chemico-biological …, 2013 - Elsevier
The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
Amiodarone-induced pulmonary inflammation
BD Wilson, CE Clarkson, ML Lippmann - Am Rev Respir Dis, 1991 - atsjournals.org
Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
Pulmonary accumulation of amiodarone and N-desethylamiodarone
BD Wilson, ML Lippmann - Am Rev Respir Dis, 1990 - atsjournals.org
Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …
Amiodarone pulmonary toxicity
ED Chan, TE King - 2007 - uptodate.com
Pulmonary toxicity is among the most serious adverse effects of amiodarone [1]. Several
forms of pulmonary disease occur among patients treated with amiodarone, including …
forms of pulmonary disease occur among patients treated with amiodarone, including …
Amiodarone-induced pulmonary toxicity in the rat
BD Wilson, AJ Jaworski, ME Donner, ML Lippmann - Lung, 1989 - Springer
A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …
The 1994 Veylien Henderson Award of the Society of Toxicology of Canada. Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity
TE Massey, RG Leeder, E Rafeiro… - Canadian journal of …, 1995 - cdnsciencepub.com
Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces
numerous adverse effects. The most critical of these is pulmonary toxicity because of the …
numerous adverse effects. The most critical of these is pulmonary toxicity because of the …
[HTML][HTML] Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro
R Bargout, A Jankov, E Dincer… - … of Physiology-Lung …, 2000 - journals.physiology.org
The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …