Isradipine: Overall clinical experience in hypertension in the United States

H Miller - Journal of cardiovascular pharmacology, 1990 - journals.lww.com
Isradipine is a new dihvdropvridine calcium antagonist shown to he efficacious, safe, and
well tolerated in the treatment of hypertension, regardless of patient age or race. There has …

Bioavailability and pharmacokinetics of isradipine after oral and intravenous administration: half‐life shorter than expected?

HR Christensen, K Antonsen… - Pharmacology & …, 2000 - Wiley Online Library
Isradipine is a calcium channel‐blocking agent of the dihydropyridine type, used in the
treatment of hypertension. A terminal half‐life of 8–9 hr has been reported, in several …

A long-term study comparing lacidipine and nifedipine SR in hypertensive patients: safety data

G Leonetti, S Salvi - Journal of Cardiovascular Pharmacology, 1994 - journals.lww.com
The clinical safety of lacidipine, a new dihydropyridine calcium antagonist, has been
assessed in a longterm, comparative study in hypertensive patients. Slowrelease (SR) …

Central hemodynamics and brachial artery compliance during therapy with isradipine, a new calcium antagonist

OK Andersson, B Persson, BR Widgren… - Journal of …, 1990 - journals.lww.com
Seventeen middle-aged males with sustained essential hypertension (WHO stage II) and
diastolic blood pressures (BP) exceeding 100 mm Hg during a placebo run-in period …

Antihypertensive effect of diltiazem administered once and twice daily.

V Mooser, B Waeber, J Nussberger… - Journal of Human …, 1988 - europepmc.org
This study was undertaken to compare the antihypertensive effect of diltiazem administered
once or twice daily. After a two week wash-out period, eight hypertensive patients were …

Hemodynamic response, safety, and efficacy of isradipine in the treatment of essential hypertension

B Dahlöf - The American Journal of Medicine, 1989 - Elsevier
The hemodynamic response achieved by isradipine is balanced; there is a marked
decrease in total peripheral resistance with no clinically significant tachycardia or …

Comparison of blood pressure control with amlodipine and controlled‐release isradipine: an open‐label, drug substitution study

M Ganz, R Mokabberi, DA Sica - The Journal of Clinical …, 2005 - Wiley Online Library
An open‐label drug substitution study showed that controlled‐release isradipine (Dynacirc‐
CR) can be safely substituted for amlodipine on a mg‐for‐mg basis in patients with mild‐to …

Comparison of isradipine and diltiazem in the treatment of essential hypertension

A Vermeulen, A Wester, PFA Willemse… - The American Journal of …, 1988 - Elsevier
Ninety-five patients with mild to moderate essential hypertension were randomly treated for
10 weeks with increasing doses of isradipine twice daily (average dose, 13.7±0.8 mg per …

Isradipine in the Treatment of Hypertension: Some Additional Effects Observed During a One-Year Study

O Mayer, H Polivkova… - American Journal of …, 1991 - academic.oup.com
After a placebo run-in phase of four weeks' duration, 1.25 mg or 2.5 mg isradipine twice daily
orally was administered for one year to 23 patients who had been diagnosed as …

A multicenter comparison of the safety and efficacy of isradipine and enalapril in the treatment of hypertension

GM Eisner, BF Johnson, FG McMahon… - American Journal of …, 1991 - academic.oup.com
This multicenter trial compared the efficacy and safety of isradipine and enalapril in 160
patients with essential hypertension. Patients received isradipine or enalapril for 10 weeks …