Dopamine and glutamate systems are both involved in cognitive, behavioral, and motor
processes. Dysfunction of dopamine–glutamate interplay has been suggested in several …

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …

Schizophrenia is one of the most debilitating psychiatric diseases with a lifetime prevalence
of approximately 1%. Although the specific molecular underpinnings of schizophrenia are …

Abnormal activity of the dopamine system has been implicated in several psychiatric and
neurological illnesses; however, lack of knowledge about the precise sites of dopamine …

The physical and functional interactions between serotonin–glutamate and serotonin–
dopamine signaling have been suggested to be involved in psychosis pathophysiology and …

Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as
PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism …

Emerging evidence from genomics, post-mortem, and preclinical studies point to a potential
dysregulation of molecular signaling at postsynaptic density (PSD) in schizophrenia …

D2 dopamine receptors (D2Rs) represent an important class of receptors in the
pharmacological development of novel therapeutic drugs for the treatment of schizophrenia …

Changes in dopaminergic function can be regulated by receptor-receptor interaction, or
interaction with other proteins with dopamine receptors, and/or elements of the downstream …

There is a growing interest in new molecular targets for antipsychotic therapy. Multiple signal
transduction systems have been recently implicated in the pathophysiology of …