The interaction of ryanodine and derivatives of ryanodine with the high affinity binding site
on the ryanodine receptor (RyR) channel brings about a characteristic modification of …

In previous studies, we have demonstrated that the interaction of ryanoids with the
sarcoplasmic reticulum Ca2+-release channel [ryanodine receptor (RyR)] incorporated into …

We have investigated the influence of transmembrane holding potential on the kinetics of
interaction of a cationic ryanoid, 8β-amino-9α-hydroxyryanodine, with individual ryanodine …

The interaction of ryanodine with the ryanodine receptor (RyR) produces profound changes
in channel function. Open probability increases dramatically and conductance is reduced. In …

Ryanodine binds with high affinity and specificity to a class of Ca2+-release channels known
as ryanodine receptors (RyR). The interaction with RyR results in a dramatic alteration in …

The following sections are included: WHAT DOES THE RYANODINE RECEPTOR (RyR)
CHANNEL DO? CHARACTERIZATION OF ION HANDLING BY THE RyR CHANNEL IS THE …

The binding of ryanodine to a high affinity site on the sarcoplasmic reticulum Ca2+-release
channel results in a dramatic alteration in both gating and ion handling; the channel enters a …

We have investigated the interactions of a novel anionic ryanoid, 10-O-succinoylryanodol,
with individual mammalian cardiac muscle ryanodine receptor channels under voltage …

In an earlier investigation, we demonstrated that the likelihood of interaction of a positively
charged ryanoid, 21-amino-9α-hydroxyryanodine, with the sarcoplasmic reticulum Ca2+ …

By interacting with more than one site, ryanoids induce multiple effects on calcium-release
channels. To date, the kinetics of interaction of only one of these sites has been …