Background Paclitaxel is an antimitotic antitumour drug highly effective against a broad
range of cancers considered refractory to conventional chemotherapy. One of the main …

Paclitaxel often induces persistent painful neuropathy as its most common treatment-limiting
side effect. Little is known concerning the underlying mechanisms. Given the prominent role …

Background: Although paclitaxel is a frontline antineoplastic agent for treatment of solid
tumors, the paclitaxel-evoked pain syndrome is a serious problem for patients. There is …

Background: Paclitaxel is an effective chemotherapeutic agent widely used for the treatment
of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …

Painful peripheral neuropathy is a serious dose-limiting side effect of paclitaxel therapy,
which unfortunately often happens during the optimal clinical management of chemotherapy …

Paclitaxel‐induced neuropathic pain is a major dose‐limiting side effect of paclitaxel
therapy. This study characterises a variety of rat behavioural responses induced by …

Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which
significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that …

Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively
extends the progression-free survival of breast, lung, and ovarian cancer patients. However …