Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in …

DS Carson, GE Hunt, AJ Guastella, L Barber… - Addiction …, 2010 - Wiley Online Library
Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in
the treatment of drug dependence and drug withdrawal. Oxytocin reduces …

Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats

DS Carson, JL Cornish, AJ Guastella, GE Hunt… - …, 2010 - Elsevier
There is emerging evidence that the neuropeptide oxytocin may be utilised as a treatment
for various psychopathologies, including drug addictions. Here we used an animal model to …

Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent …

P Zanos, SR Wright, P Georgiou, JH Yoo… - Pharmacology …, 2014 - Elsevier
There is mounting evidence that the neuropeptide oxytocin is a possible candidate for the
treatment of drug addiction. Oxytocin was shown to reduce methamphetamine self …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Role of oxytocin in the neuroadaptation to drugs of abuse

Z Sarnyai, GL Kovács - Psychoneuroendocrinology, 1994 - Elsevier
Oxytocin (OXT), a neurohypophyseal hormone, has a wide range of behavioral effects
outside its classic peripheral endocrine functions. OXT involvement in adaptive central …

Oxytocin and addiction: a review

GL Kovács, Z Sarnyai, G Szabó - Psychoneuroendocrinology, 1998 - Elsevier
Neuropeptides affect adaptive central nervous system processes related to opiate ethanol
and cocaine addiction. Oxytocin (OXT), a neurohypophyseal neuropeptide synthesized in …

Systemic oxytocin administration alters mesolimbic dopamine release in mice

MK Estes, TG Freels, WT Prater, DB Lester - Neuroscience, 2019 - Elsevier
Growing research indicates oxytocin may be involved in relieving anxiety and attenuating
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …

Chronic methamphetamine self‐administration dysregulates oxytocin plasma levels and oxytocin receptor fibre density in the nucleus accumbens core and …

SJ Baracz, LM Parker, AS Suraev… - Journal of …, 2016 - Wiley Online Library
The neuropeptide oxytocin attenuates reward and abuse for the psychostimulant
methamphetamine (METH). Recent findings have implicated the nucleus accumbens (NA c) …

The neurocircuitry involved in oxytocin modulation of methamphetamine addiction

SJ Baracz, JL Cornish - Frontiers in neuroendocrinology, 2016 - Elsevier
The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the
psychostimulant methamphetamine, has been examined with increased ferocity in recent …

Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine‐seeking behaviour in rats

SJ Baracz, NA Everett, IS McGregor… - Addiction …, 2016 - Wiley Online Library
The psychostimulant methamphetamine (METH) is an addictive illicit drug. Systemic
administration of the neuropeptide oxytocin modulates METH‐related reward and METH …