Complex dietary sphingolipids such as sphingomyelin and glycosphingolipids have been
reported to inhibit the development of colon cancer. This protective role may be the result of …

Complex dietary sphingolipids such as sphingomyelin and glycosphingolipids have been
reported to inhibit development of colon cancer. This protective role may be the result of …

Intestinal cells are regularly exposed to sphingolipid metabolites, ie, ceramide and
sphingoid bases, after hydrolysis of complex sphingolipids from the diet. These metabolites …

The apoptotic effects of plant sphingoid bases prepared from wheat-flour cerebroside on
human colorectal cancer DLD-1 cells were examined. The viability of DLD-1 cells treated …

Sphingoid bases are cytotoxic for many cancer cell lines and are thought to contribute to
suppression of intestinal tumorigenesis in vivo by ingested sphingolipids. This study …

The sphingoid base sphinganine induces apoptosis in HT-29 human colon cancer cells
more potently than other bioactive sphingolipid metabolites sphingosine and C 2-ceramide …

In the study of apoptosis initiated by various signals including ligands binding to cell
membrane receptors such as Fas and TNFRI, the sphingomyelin pathway and its resulting …

Ceramide has been implicated as an important component of radiation-induced apoptosis of
human prostate cancer cells. We examined the role of the sphingolipid metabolites …

Dietary sphingolipids inhibit chemically induced colon cancer in mice. The most likely
mediators of this effect are the metabolites ceramide (Cer) and sphingosine, which induce …

Through modifications in the fine membrane structure, cell–cell or cell–matrix interactions,
and/or modulation of intracellular signaling pathways, sphingolipids can affect the …