[HTML][HTML] The effect of rifampicin-based antitubercular therapy and cytochrome P450 2B6 genotype on efavirenz mid-dosing interval concentrations in a South African …
Background Rifampicin may decrease efavirenz concentrations by inducing expression of
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G> T polymorphism on efavirenz concentrations in adults in South Africa
Background Rifampicin induces expression of the cytochrome P450 isoenzyme 2B6
(CYP2B6), which metabolizes efavirenz. The CYP2B6 516G> T polymorphism impairs …
(CYP2B6), which metabolizes efavirenz. The CYP2B6 516G> T polymorphism impairs …
CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure
JK Mukonzo, S Nanzigu, P Waako… - …, 2014 - Future Medicine
Aim: We investigated the effects of rifampicin-based anti-TB treatment on plasma efavirenz
exposure and the implications of CYP2B6 genotype. Patients & methods: Antiretroviral …
exposure and the implications of CYP2B6 genotype. Patients & methods: Antiretroviral …
Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype
The impact of anti-tuberculosis co-treatment on efavirenz (EFV) exposure is still uncertain as
contradictory reports exist, and the relevance of CYP2B6* 6 genetic polymorphism on …
contradictory reports exist, and the relevance of CYP2B6* 6 genetic polymorphism on …
Efavirenz dosing: influence of drug metabolizing enzyme polymorphisms and concurrent tuberculosis treatment
TN Gengiah, JH Botha, N Yende-Zuma… - Antiviral …, 2015 - journals.sagepub.com
Background Rifampicin-based tuberculosis (TB) treatment alters efavirenz (EFV) clearance.
Polymorphisms in important drug metabolizing enzymes and the implications for EFV dosing …
Polymorphisms in important drug metabolizing enzymes and the implications for EFV dosing …
Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study
A Habtewold, E Makonnen, W Amogne… - …, 2015 - Future Medicine
Aims: The current HIV treatment guidelines are inconsistent about the need for weight-based
efavirenz dose adjustment during rifampicin containing antituberculosis (anti-TB) …
efavirenz dose adjustment during rifampicin containing antituberculosis (anti-TB) …
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma …
Efavirenz (EFV) exhibits interindividual pharmacokinetic variability caused by differences in
cytochrome P450 (CYP) expression. Most tuberculosis (TB) drugs interact with the CYP …
cytochrome P450 (CYP) expression. Most tuberculosis (TB) drugs interact with the CYP …
CYP2B6 G516T Polymorphism but Not Rifampin Coadministration Influences Steady-State Pharmacokinetics of Efavirenz in Human Immunodeficiency Virus-Infected …
G Ramachandran, AK Hemanth Kumar… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The dose of efavirenz during concomitant rifampin (RMP) administration is a matter of
debate. We studied the influence of RMP coadministration on the steady-state …
debate. We studied the influence of RMP coadministration on the steady-state …
Functional CYP2B6 variants and virologic response to an efavirenz-containing regimen in Port-au-Prince, Haiti
DW Haas, P Severe, MA Jean Juste… - Journal of …, 2014 - academic.oup.com
Objectives Efavirenz is widely prescribed for HIV-1 infection. Three polymorphisms in
CYP2B6 define plasma efavirenz trough concentration strata that vary across an∼ 10-fold …
CYP2B6 define plasma efavirenz trough concentration strata that vary across an∼ 10-fold …
Effects of rifampicin, CYP2B6 and ABCB1 polymorphisms on efavirenz plasma concentration in Chinese patients living with HIV and tuberculosis
L Zhang, X Meng, P Dong, T Qi… - … journal of STD & …, 2023 - journals.sagepub.com
Background Tuberculosis (TB) is the leading opportunistic infection of people living with
human immunodeficiency virus (HIV; PLWH). Cytochrome P450 (CYP) 2B6 and ATP …
human immunodeficiency virus (HIV; PLWH). Cytochrome P450 (CYP) 2B6 and ATP …