Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma
SL Potter, J Reuther, R Chandramohan… - Pediatric Blood & …, 2021 - Wiley Online Library
Background Pediatric papillary thyroid carcinoma (PTC) is clinically and biologically distinct
from adult PTC. We sequenced a cohort of clinically annotated pediatric PTC cases enriched …
from adult PTC. We sequenced a cohort of clinically annotated pediatric PTC cases enriched …
Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma
Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease.
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …
Unique molecular signatures are associated with aggressive histology in pediatric differentiated thyroid cancer
KP Mollen, AD Shaffer, L Yip, SE Monaco, P Huyett… - Thyroid, 2022 - liebertpub.com
Background: Molecular testing (MT) enhances the diagnostic accuracy of thyroid fine-needle
aspiration biopsy, reducing the need for diagnostic lobectomy in adult patients with …
aspiration biopsy, reducing the need for diagnostic lobectomy in adult patients with …
RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas
B Pekova, V Sykorova, S Dvorakova, E Vaclavikova… - Thyroid, 2020 - liebertpub.com
Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …
NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States
ML Prasad, M Vyas, MJ Horne, RK Virk, R Morotti… - Cancer, 2016 - Wiley Online Library
BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …
(PTC), has been recently reported in children. METHODS The histopathology of 28 …
Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma
Pediatric papillary thyroid carcinomas (pPTCs) are often indolent tumors with excellent long-
term outcome, although subsets of cases are clinically troublesome and recur. Although it is …
term outcome, although subsets of cases are clinically troublesome and recur. Although it is …
Fusion oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers
AT Franco, JC Ricarte-Filho, A Isaza… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …
[HTML][HTML] Mutational analysis using next generation sequencing in pediatric thyroid cancer reveals BRAF and fusion oncogenes are common
RS Newfield, W Jiang, DX Sugganth… - International Journal of …, 2022 - Elsevier
Background We previously described mutation rates of BRAF V600E, RAS, RET-PTC and
PAX8-PPARγ in pediatric subjects with well-differentiated thyroid cancer (WDTC). We …
PAX8-PPARγ in pediatric subjects with well-differentiated thyroid cancer (WDTC). We …
Distant metastases from childhood differentiated thyroid carcinoma: clinical course and mutational landscape
M Nies, R Vassilopoulou-Sellin… - The Journal of …, 2021 - academic.oup.com
Context Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are
uncommon and published studies are limited. Objective This work aimed to describe the …
uncommon and published studies are limited. Objective This work aimed to describe the …
The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer
JC Ricarte-Filho, AT Franco - Current Opinion in Endocrine and Metabolic …, 2023 - Elsevier
Thyroid cancer is a rare cancer in the pediatric population, but incidences are rising. Thyroid
tumors in children have a unique set of clinical, pathological and molecular features, and …
tumors in children have a unique set of clinical, pathological and molecular features, and …
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