A unifying mechanism for protein transport through the core bacterial Sec machinery

WJ Allen, I Collinson - Open Biology, 2023 - royalsocietypublishing.org
Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

Breaking on through to the other side: protein export through the bacterial Sec system

KE Chatzi, MF Sardis, S Karamanou… - Biochemical …, 2013 - portlandpress.com
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway

K Stephenson - Molecular membrane biology, 2005 - Taylor & Francis
All living organisms, no matter how simple or complex, possess the ability to translocate
proteins across biological membranes and into different cellular compartments. Although a …

Protein transport across the bacterial plasma membrane by the Sec pathway

D Smets, MS Loos, S Karamanou, A Economou - The Protein Journal, 2019 - Springer
More than a third of all bacterial polypeptides, comprising the 'exportome', are transported to
extracytoplasmic locations. Most of the exportome is targeted and inserts into …

Structure and function of the bacterial Sec translocon

VAM Gold, F Duong, I Collinson - Molecular membrane biology, 2007 - Taylor & Francis
Bacteria and archaea possess a protein complex in the plasma membrane that governs
protein secretion and membrane protein insertion. Eukaryotes carry homologues in the …

The SecY complex: conducting the orchestra of protein translocation

K Dalal, F Duong - Trends in cell biology, 2011 - cell.com
Like the conductor of an orchestra, the Sec protein translocation channel is the platform
needed to bring together the many different players required for the constitutive and …

The Sec protein-translocation pathway

H Mori, K Ito - Trends in microbiology, 2001 - cell.com
The Sec machinery (or translocase) provides a major pathway of protein translocation from
the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts …

[HTML][HTML] The Sec-dependent pathway

J Beckwith - Research in microbiology, 2013 - Elsevier
The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial
periplasm and outer membrane was the first secretion pathway to be discovered in bacteria …

Effects of SecE Depletion on the Inner and Outer Membrane Proteomes of Escherichia coli

L Baars, S Wagner, D Wickström… - Journal of …, 2008 - Am Soc Microbiol
The Sec translocon is a protein-conducting channel that allows polypeptides to be
transferred across or integrated into a membrane. Although protein translocation and …