The Na+/K+-ATPase (NKA) is the main route for Na+ extrusion from cardiac myocytes.
Different NKA α-subunit isoforms are present in the heart. NKA-α1 is predominant, although …

Augmented and slowed late Na+ current (I NaL) is implicated in action potential duration
variability, early afterdepolarizations, and abnormal Ca2+ handling in human and canine …

Objective: The aim of the present study was to investigate the functional activity and
expression of the sarcolemmal Na+/Ca2+-exchanger in the failing human heart. Methods …

C. Allyson Walker, BA Francis G. Spinale, MD, PhD myocyte sarcolemma is to place it in the
context of the phases of the action potential. A representative ventricular myocyte action …

1 To investigate the regulation of native cardiac Na+‐Ca2+ exchange by cytoplasmic Na+
(Na+ i) and Ca2+ (Ca2+ i), we recorded the Na+‐Ca2+ exchange current (INa‐Ca) from …

Ca handling [1, 2] that can contribute to diastolic and/or an arrhythmogenic non-ischemic HF
rabbit model (induced systolic dysfunction and arrhythmias [1, 3]. However, there by aortic …

Cardiac sodium pumps (Na, K-ATPase) influence cell calcium and contractility by generating
the Na+ gradient driving Ca++ extrusion via the Na+/Ca++ exchanger (NCX), and are the …

The Na+ gradient produced across the cardiac sarcolemma by the ATP-dependent Na+-
pump is a constant source of energy for Na+-dependent transporters. The plasma …

Historically, increase in cell Na content during ischemic and hypoxic episodes were thought
to result from impaired ATP production causing decreased Na (+)-K (+)-ATPase activity …

Intracellular Na and Arrhythmia. A number of clinical cardiac disorders may be associated
with a rise of the intracellular Na concentration (Nai) in heart muscle. A clear example is …