Pulmonary toxicity of instilled silver nanoparticles: influence of size, coating and rat strain

J Seiffert, F Hussain, C Wiegman, F Li, L Bey, W Baker… - PloS one, 2015 - journals.plos.org
Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP)
respiratory toxicity that may also depend on the lung inflammatory state. We compared the …

Pro-inflammatory versus immunomodulatory effects of silver nanoparticles in the lung: the critical role of dose, size and surface modification

F Alessandrini, A Vennemann, S Gschwendtner… - Nanomaterials, 2017 - mdpi.com
The growing use of silver nanoparticles (Ag-NPs) in consumer products raises concerns
about their toxicological potential. The purpose of the study was to investigate the size-and …

Pulmonary effects of silver nanoparticle size, coating, and dose over time upon intratracheal instillation

RM Silva, DS Anderson, LM Franzi… - Toxicological …, 2015 - academic.oup.com
Abstract Silver nanoparticles (Ag NPs) can be found in myriad consumer products, medical
equipment/supplies, and public spaces. However, questions remain regarding the risks …

Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

HC Chuang, TC Hsiao, CK Wu, HH Chang… - International journal …, 2013 - Taylor & Francis
Silver nanoparticles (AgNP) have been associated with the exacerbation of airway
hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy and …

Difference in the toxicity mechanism between ion and nanoparticle forms of silver in the mouse lung and in macrophages

Y Arai, T Miyayama, S Hirano - Toxicology, 2015 - Elsevier
The health effects of silver nanoparticles (AgNPs) have not been well investigated, despite
AgNPs now being widely used in consumer products. We investigated the metabolic …

Aerosolized silver nanoparticles in the rat lung and pulmonary responses over time

RM Silva, DS Anderson, J Peake… - Toxicologic …, 2016 - journals.sagepub.com
Silver nanoparticle (Ag NP) production methods are being developed and refined to
produce more uniform Ag NPs through chemical reactions involving silver salt solutions …

[HTML][HTML] Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

N Haberl, S Hirn, A Wenk, J Diendorf… - Beilstein journal of …, 2013 - beilstein-journals.org
Silver nanoparticles (AgNP) are among the most promising nanomaterials, and their usage
in medical applications and consumer products is growing rapidly. To evaluate possible …

Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity

DJ Botelho, BF Leo, CB Massa, S Sarkar… - …, 2016 - Taylor & Francis
Multiple studies have examined the direct cellular toxicity of silver nanoparticles (AgNPs).
However, the lung is a complex biological system with multiple cell types and a lipid-rich …

Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study

HM Braakhuis, FR Cassee, PHB Fokkens… - …, 2016 - Taylor & Francis
A number of studies have shown that induction of pulmonary toxicity by nanoparticles of the
same chemical composition depends on particle size, which is likely in part due to …

Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles

HM Braakhuis, I Gosens, P Krystek, JAF Boere… - Particle and fibre …, 2014 - Springer
Background Although silver nanoparticles are currently used in more than 400 consumer
products, it is not clear to what extent they induce adverse effects after inhalation during …