Rodent models of leptin receptor deficiency are less sensitive to amylin
The pancreatic hormone amylin is released from beta cells following nutrient ingestion and
contributes to the control of body weight and glucose homeostasis. Amylin reduces food …
contributes to the control of body weight and glucose homeostasis. Amylin reduces food …
[HTML][HTML] AdipoRon treatment induces a dose-dependent response in adult hippocampal neurogenesis
TH Lee, BR Christie, H van Praag, K Lin… - International Journal of …, 2021 - mdpi.com
AdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti-atherogenic, and
anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross …
anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross …
Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease
G McGregor, J Harvey - Neuropharmacology, 2018 - Elsevier
Accumulating evidence indicates that diet and body weight are important factors associated
with Alzheimer's disease (AD), with a significant increase in AD risk linked to mid-life obesity …
with Alzheimer's disease (AD), with a significant increase in AD risk linked to mid-life obesity …
Leptin resistance and hippocampal behavioral deficits
The adipocyte-derived hormone leptin is an important regulator of body weight and
metabolism through activation of brain leptin receptors expressed in regions such as the …
metabolism through activation of brain leptin receptors expressed in regions such as the …
Amylin receptor components and the leptin receptor are co‐expressed in single rat area postrema neurons
Amylin is a pancreatic β‐cell hormone that acts as a satiating signal to inhibit food intake by
binding to amylin receptors (AMY s) and activating a specific neuronal population in the area …
binding to amylin receptors (AMY s) and activating a specific neuronal population in the area …
Short‐term high‐fat diet increases the presence of astrocytes in the hypothalamus of C57 BL 6 mice without altering leptin sensitivity
Diet‐induced obesity is associated with hypothalamic inflammation and this phenomenon
has been proposed to explain leptin resistance. In the present study, we used a short‐term …
has been proposed to explain leptin resistance. In the present study, we used a short‐term …
Leptin dysfunction and Alzheimer's disease: evidence from cellular, animal, and human studies
MJ McGuire, M Ishii - Cellular and molecular neurobiology, 2016 - Springer
There is accumulating evidence from epidemiological studies that changes in body weight
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …
[HTML][HTML] Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice
TH Lee, Ahadullah, BR Christie, K Lin, PM Siu… - Molecular …, 2021 - Springer
Administration of exercise mimetic drugs could be a novel therapeutic approach to combat
comorbid neurodegeneration and metabolic syndromes. Adiponectin is an adipocyte …
comorbid neurodegeneration and metabolic syndromes. Adiponectin is an adipocyte …
Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
Leptin is a centrally acting hormone controlling metabolic pathways. Recently, it was shown
that leptin can reduce amyloid β levels both in vitro and in vivo. Herein, phosphorylation of …
that leptin can reduce amyloid β levels both in vitro and in vivo. Herein, phosphorylation of …
Amylin selectively signals onto POMC neurons in the arcuate nucleus of the hypothalamus
TA Lutz, B Coester, L Whiting, AA Dunn-Meynell… - Diabetes, 2018 - Am Diabetes Assoc
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes
with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) …
with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) …