Rodent models of leptin receptor deficiency are less sensitive to amylin

S Duffy, TA Lutz, CN Boyle - American Journal of …, 2018 - journals.physiology.org
The pancreatic hormone amylin is released from beta cells following nutrient ingestion and
contributes to the control of body weight and glucose homeostasis. Amylin reduces food …

[HTML][HTML] AdipoRon treatment induces a dose-dependent response in adult hippocampal neurogenesis

TH Lee, BR Christie, H van Praag, K Lin… - International Journal of …, 2021 - mdpi.com
AdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti-atherogenic, and
anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross …

Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease

G McGregor, J Harvey - Neuropharmacology, 2018 - Elsevier
Accumulating evidence indicates that diet and body weight are important factors associated
with Alzheimer's disease (AD), with a significant increase in AD risk linked to mid-life obesity …

Leptin resistance and hippocampal behavioral deficits

C Van Doorn, VA Macht, CA Grillo, LP Reagan - Physiology & behavior, 2017 - Elsevier
The adipocyte-derived hormone leptin is an important regulator of body weight and
metabolism through activation of brain leptin receptors expressed in regions such as the …

Amylin receptor components and the leptin receptor are co‐expressed in single rat area postrema neurons

CG Liberini, CN Boyle, C Cifani… - European journal of …, 2016 - Wiley Online Library
Amylin is a pancreatic β‐cell hormone that acts as a satiating signal to inhibit food intake by
binding to amylin receptors (AMY s) and activating a specific neuronal population in the area …

Short‐term high‐fat diet increases the presence of astrocytes in the hypothalamus of C57 BL 6 mice without altering leptin sensitivity

E Balland, MA Cowley - Journal of Neuroendocrinology, 2017 - Wiley Online Library
Diet‐induced obesity is associated with hypothalamic inflammation and this phenomenon
has been proposed to explain leptin resistance. In the present study, we used a short‐term …

Leptin dysfunction and Alzheimer's disease: evidence from cellular, animal, and human studies

MJ McGuire, M Ishii - Cellular and molecular neurobiology, 2016 - Springer
There is accumulating evidence from epidemiological studies that changes in body weight
are associated with Alzheimer's disease (AD) from mid-life obesity increasing the risk of …

[HTML][HTML] Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice

TH Lee, Ahadullah, BR Christie, K Lin, PM Siu… - Molecular …, 2021 - Springer
Administration of exercise mimetic drugs could be a novel therapeutic approach to combat
comorbid neurodegeneration and metabolic syndromes. Adiponectin is an adipocyte …

Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells

SJ Greco, S Sarkar, JM Johnston, X Zhu, B Su… - Biochemical and …, 2008 - Elsevier
Leptin is a centrally acting hormone controlling metabolic pathways. Recently, it was shown
that leptin can reduce amyloid β levels both in vitro and in vivo. Herein, phosphorylation of …

Amylin selectively signals onto POMC neurons in the arcuate nucleus of the hypothalamus

TA Lutz, B Coester, L Whiting, AA Dunn-Meynell… - Diabetes, 2018 - Am Diabetes Assoc
Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes
with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) …