The folates are made up of a pterdine ring attached to a p-aminobenzoate and a
polyglutamyl chain. The active form is tetrahydrofolate which can have C1 units enzymically …

The vitamins folic acid, B12 and B6 and B2 are the source of coenzymes which participate in
one carbon metabolism. In this metabolism, a carbon unit from serine or glycine is …

The studies discussed in this review support the view that biochemical and clinical
symptoms common to both folate and vitamin B12 deficiency are due to the induction of a …

Folate deficiency causes anaemia owing to impaired purine and pyrimidine biosynthesis.
Vitamin B12 deficiency causes an identical anaemia owing to metabolic trapping of …

Vitamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires
vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine …

1. The isolated perfused rat liver and suspensions of isolated rat hepatocytes fail to form
glucose from histidine, in contrast with the liver in vivo. Both rat liver preparations readily …

A dietary factor that prevented megaloblastic anemia of pregnancy and animal growth
factors and lactic acid bacteria growth factors was studied during the 1930s. Liver, yeast …

This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a
particular emphasis on how it is, or may be, involved in many disease processes. Folic acid …

It is suggested that in man the methyl folate trap is a normal physiological response to
impending methyl group deficiency resulting from a very low supply of methionine. This …

The critical disturbance of folate metabolism caused by vitamin B12 deficiency which results
in megalo‐blastic anaemia remains controversial. Vitamin B12 is required in the methionine …