Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy

Y Wu, J De Asis-Cruz, C Limperopoulos - Molecular Psychiatry, 2024 - nature.com
In-utero exposure to maternal psychological distress is increasingly linked with disrupted
fetal and neonatal brain development and long‐term neurobehavioral dysfunction in …

A transient placental source of serotonin for the fetal forebrain

A Bonnin, N Goeden, K Chen, ML Wilson, J King… - Nature, 2011 - nature.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental
processes through maternal–fetal interactions that have long-term mental health …

Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain

JA Bravo, TG Dinan, JF Cryan - Frontiers in molecular neuroscience, 2014 - frontiersin.org
Early-life experience plays a major role in the stress response throughout life. Neonatal
maternal separation (MS) is an animal model of depression with an altered serotonergic …

In utero exposure to serotonergic drugs alters neonatal expression of 5-HT1A receptor transcripts: a quantitative RT-PCR study

JM Lauder, J Liu, DR Grayson - International Journal of Developmental …, 2000 - Elsevier
In embryonic rat brain, serotonin (5-HT) acts as a differentiation signal for 5-HT neurons and
their target cells during midgestation. Serotonin receptors expressed during this period …

A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders

R Rose'Meyer - Molecular Autism, 2013 - Springer
The diagnosis of autism spectrum disorder (ASD) during early childhood has a profound
effect not only on young children but on their families. Aside from the physical and …

The serotonin 5-HT3 receptor: a novel neurodevelopmental target

M Engel, MP Smidt, JA Hooft - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Serotonin (5-hydroxytryptamine, 5-HT), next to being an important neurotransmitter, recently
gained attention as a key-regulator of pre-and postnatal development in the mammalian …

[PDF][PDF] Intrauterine factors as determinants of depressive disorder

M Weinstock - Isr J psychiatry relat sci, 2010 - researchgate.net
Although the etiology of major depressive disorder (MDD) is unknown, it is precipitated in
susceptible individuals by adverse events. this review examines the role of intrauterine …

Developmentally regulated serotonin 5-HT2B receptors

CG Nebigil, N Etienne, B Schaerlinger, P Hickel… - International Journal of …, 2001 - Elsevier
Serotonin (5-hydroxytryptamine, 5-HT) binds to numerous cognate receptors to initiate its
biological effects. In this review, we have focused on the 5-HT2B receptor to address how …

Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine

S Pei, L Liu, Z Zhong, H Wang, S Lin, J Shang - Scientific Reports, 2016 - nature.com
Fluoxetine is widely used to treat depression, including depression in pregnant and
postpartum women. Studies suggest that fluoxetine may have adverse effects on offspring …

Placental HTR2A methylation is associated with infant neurobehavioral outcomes

AG Paquette, C Lesseur, DA Armstrong, DC Koestler… - Epigenetics, 2013 - Taylor & Francis
The serotonin receptor, HTR2A, exhibits placental expression and function and can be
controlled through DNA methylation. The relationship between methylation of HTR2A in the …